正常和炎症状态下人牙髓中的环磷酸腺苷磷酸二酯酶活性

Cyclic Amp phosphodiesterase activity in normal and inflamed human dental pulp.

作者信息

Spoto G, Menna V, Serra E, Santoleri F, Perfetti G, Ciavarelli L, Trentini P

机构信息

Department of Applied Sciences of Oral and Dental Diseases, University of Chieti, Italy.

出版信息

Int J Immunopathol Pharmacol. 2004 Sep-Dec;17(3 Suppl):11-5.

PMID:16857100

Abstract

Cyclic AMP phosphodiesterase (cAMP PDE) seems to be important in pulp tissues. High levels of cAMP PDE have been demonstrated to be in dental pulp cells. In the present study cAMP PDE activity was analyzed in normal healthy human dental pulps, in reversible pulpitis and in irreversible pulpitis. Enzymatic cAMP PDE control values for normal healthy pulps were 12.14 +/- 3.74 nmols/mg of proteins. In reversible pulpitis the cAMP PDE activity increased almost 2.5 times. In irreversible pulpitis specimens the values increased 4.5 times compared with normal healthy pulps activity. The differences between the groups (control vs. reversible pulpitis and vs. irreversible pulpitis) were statistically significant. These results could point to a role of cAMP PDE in the initial pulp response after injury.

摘要

环磷酸腺苷磷酸二酯酶（cAMP PDE）似乎在牙髓组织中很重要。已证实在牙髓细胞中存在高水平的cAMP PDE。在本研究中，对正常健康人的牙髓、可逆性牙髓炎和不可逆性牙髓炎中的cAMP PDE活性进行了分析。正常健康牙髓的酶促cAMP PDE对照值为12.14±3.74 nmol/mg蛋白质。在可逆性牙髓炎中，cAMP PDE活性几乎增加了2.5倍。与正常健康牙髓活性相比，不可逆性牙髓炎标本中的值增加了4.5倍。各组之间（对照组与可逆性牙髓炎组以及与不可逆性牙髓炎组）的差异具有统计学意义。这些结果可能表明cAMP PDE在损伤后牙髓的初始反应中起作用。