Tulunoglu O, Alacam A, Bastug M, Yavuzer S
Department of Pedodontics Gazi University, Faculty of Dentistry, Ankara, Turkey.
J Clin Pediatr Dent. 1998 Summer;22(4):341-5.
The free radicals play an important role in the tissue damage. Oxygen-derived free radicals are controlled by various cellular defense mechanisms consisting of enzymatic such as superoxide dismutase, catalase, glutathion peroxidase and nonenzymatic scavenger components. Superoxide dismutase (SOD) is responsible for the dismutation of the superoxide radicals into hydrogen peroxide and molecular oxygen. In this study, pulp samples extirpated from the teeth of the 27 children between 10-15 ages which diagnosed to be healthy, reversible pulpitis or symptomatic irreversible pulpitis were evaluated for the activity of superoxide dismutase enzyme. There were statistically significant differences between healthy and reversible pulpitis, and between reversible and symptomatic irreversible pulpitis groups. The SOD activity of the reversible pulpitis group were significantly lower than the irreversible pulpitis and healthy pulp groups. The evaluation of the data revealed that the quantity of SOD as a vitality protector enzyme is low at the beginning of the inflammation as a consequence of rapidly depletion and/or destruction of this enzyme, but as the inflammation proceeds the pulp tissue showed adaptation to this situation.
自由基在组织损伤中起重要作用。氧衍生的自由基受多种细胞防御机制控制，这些机制包括超氧化物歧化酶、过氧化氢酶、谷胱甘肽过氧化物酶等酶类以及非酶清除剂成分。超氧化物歧化酶（SOD）负责将超氧自由基歧化为过氧化氢和分子氧。在本研究中，对从27名10至15岁被诊断为健康、可复性牙髓炎或症状性不可复性牙髓炎儿童的牙齿中取出的牙髓样本进行了超氧化物歧化酶活性评估。健康组与可复性牙髓炎组之间以及可复性牙髓炎组与症状性不可复性牙髓炎组之间存在统计学上的显著差异。可复性牙髓炎组的SOD活性显著低于不可复性牙髓炎组和健康牙髓组。数据评估显示，作为活力保护酶的SOD数量在炎症开始时较低，这是由于该酶的快速消耗和/或破坏所致，但随着炎症进展，牙髓组织显示出对这种情况的适应性。
