环磷酸鸟苷磷酸二酯酶活性在正常和炎症状态下人牙髓中的作用。

Cyclic GMP phosphodiesterase activity role in normal and inflamed human dental pulp.

作者信息

Spoto G, Ferrante M, D'Intino M, Rega L, Dolci M, Trentini P, Ciavarelli L

机构信息

Department of Applied Sciences of Oral and Dental Diseases, University of Chieti, Italy.

出版信息

Int J Immunopathol Pharmacol. 2004 Sep-Dec;17(3 Suppl):21-4.

PMID:16857102

Abstract

Cyclic GMP phosphodiesterase (cGMP PDE) plays an important role in pulp tissues. High levels of cGMP PDE are found in dental pulp cells. In the present study cGMP PDE activity was analyzed in normal healthy human dental pulps, in reversible pulpitis and in irreversible pulpitis. Enzymatic cGMP PDE control values for normal healthy pulps were 4.74+/-0.32 nmol/mg of proteins. In reversible pulpitis the cGMP PDE activity increased almost 3 times. In irreversible pulpitis specimens the values increased 4.5 times compared with the normal healthy pulps activity. The differences between the groups (control vs. reversible pulpitis and vs. irreversible pulpitis) were statistically significant. These results point to a role of cGMP PDE in the initial pulp response after injury.

摘要

环磷酸鸟苷磷酸二酯酶（cGMP PDE）在牙髓组织中发挥重要作用。牙髓细胞中发现高水平的cGMP PDE。在本研究中，对正常健康人牙髓、可逆性牙髓炎和不可逆性牙髓炎中的cGMP PDE活性进行了分析。正常健康牙髓的酶促cGMP PDE对照值为4.74±0.32 nmol/mg蛋白质。在可逆性牙髓炎中，cGMP PDE活性几乎增加了3倍。在不可逆性牙髓炎标本中，与正常健康牙髓活性相比，该值增加了4.5倍。各组之间（对照组与可逆性牙髓炎组以及与不可逆性牙髓炎组）的差异具有统计学意义。这些结果表明cGMP PDE在损伤后牙髓的初始反应中起作用。