小鼠巨细胞病毒感染后的存活率与脾细胞对刀豆球蛋白A反应性的相关性。
Correlation of survival from murine cytomegalovirus infection with spleen cell responsiveness to Concanavallin A.
作者信息
Booss J, Wheelock E F
出版信息
Proc Soc Exp Biol Med. 1975 Jun;149(2):443-5. doi: 10.3181/00379727-149-38824.
PMID:168587
Abstract
Spleen cells from nonlethally MCMV-infected weanling and adult DBA/2 mice had diminished responses to Con A stimulation. In contrast, only lethal MCMV infections were associated with a complete suppression of the Con A response. The immune response to SRBC was depressed even in asymptomatic infections of weanling and adult mice. A marked maturation of resistance to the lethal effects of MCMV infection was found to occur during the fourth week of life.
摘要
来自未致死性感染巨细胞病毒（MCMV）的断奶和成年DBA/2小鼠的脾细胞对刀豆蛋白A（Con A）刺激的反应减弱。相比之下，只有致死性MCMV感染与Con A反应的完全抑制有关。即使在断奶和成年小鼠的无症状感染中，对绵羊红细胞（SRBC）的免疫反应也受到抑制。发现在生命的第四周期间，对MCMV感染致死效应的抵抗力有显著成熟。
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