Heard Darryl, Towles Jennifer, Leblanc Dana
Box 100126 HSC, Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, Florida 32610-0126, USA.
J Wildl Dis. 2006 Apr;42(2):437-41. doi: 10.7589/0090-3558-42.2.437.
Four medetomidine/ketamine (M/K) doses (30 microg/kg/3 mg/kg; 40/4; 50/5; 60/6), administered by intramuscular injection, were evaluated for short-term immobilization of adult male variable flying foxes (Pteropus hypomelanus). The highest dose (60 microg/kg/6 mg/kg) produced a significantly faster induction (31 +/- 46 sec) than the lowest dose (30/3) (125 +/- 62 sec). The highest dose levels (50/5, 60/6) produced significantly longer immobilization times (52.5 +/- 25.7 min and 60.6 +/- 20.8 min, respectively) than did the lower doses (30/3, 40/4) (18.8 +/- 8.7 min and 31.0 +/- 14.3 min, respectively). The dose at which 50% of the bats were immobilized for > or = 30 min (ED(50)) was approximately 40 microg/kg/4 mg/kg. This dose produced a mean immobilization time of 31 +/- 14 min, bradypnea and bradycardia. In conclusion, a M/K dose of 50 microg/kg/5 mg/kg is recommended for greater than 30 min of relaxed immobilization in free-living variable flying foxes and is sufficient for safe collection of samples.
通过肌肉注射给予成年雄性马来大狐蝠（Pteropus hypomelanus）四种美托咪定/氯胺酮（M/K）剂量（30微克/千克/3毫克/千克；40/4；50/5；60/6），以评估其短期制动效果。最高剂量（60微克/千克/6毫克/千克）的诱导速度（31±46秒）明显快于最低剂量（30/3）（125±62秒）。最高剂量水平（50/5、60/6）的制动时间（分别为52.5±25.7分钟和60.6±20.8分钟）明显长于较低剂量（30/3、40/4）（分别为18.8±8.7分钟和�1.0±14.3分钟）。使50%的蝙蝠制动≥30分钟的剂量（ED50）约为40微克/千克/4毫克/千克。该剂量产生的平均制动时间为31±14分钟，伴有呼吸过缓和心动过缓。总之，对于自由活动的马来大狐蝠，推荐使用50微克/千克/5毫克/千克的M/K剂量进行超过30分钟的松弛制动，该剂量足以安全采集样本。
