来自中国红藻冈村凹顶藻的新型劳伦烷型倍半萜类化合物。
New laurane-type sesquiterpenoids from the Chinese red alga Laurencia okamurai Yamada.
作者信息
Li Xiao-Lu, He Wen-Fei, Li Jia, Lan Le-Fu, Li Xu-Wen, Guo Yue-Wei
机构信息
a State Key Laboratory of Drug Research , Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203 , China.
出版信息
J Asian Nat Prod Res. 2015;17(12):1146-52. doi: 10.1080/10286020.2015.1102135. Epub 2015 Dec 10.
Two new laurane-type sesquiterpenoids, debromo-3α-hydroperoxy-3-epiaplysin (1) and debromo-3β-hydroperoxyaplysin (2), together with seven known related compounds (3-9), were isolated from the Chinese red alga Laurencia okamurai. Their structures were elucidated by detailed analysis of spectroscopic data and by comparison with the literature. In bioassay, compounds 2, 4, 8, and 9 exhibited significant PTP1B inhibitory activity with IC50 values ranging from 4.9 to 14.9 μg/ml.
从中国红藻冈村凹顶藻（Laurencia okamurai）中分离出两种新的劳丹烷型倍半萜类化合物，脱溴-3α-氢过氧基-3-表阿朴藻素（1）和脱溴-3β-氢过氧基阿朴藻素（2），以及七种已知的相关化合物（3-9）。通过对光谱数据的详细分析并与文献进行比较，阐明了它们的结构。在生物测定中，化合物2、4、8和9表现出显著的蛋白酪氨酸磷酸酶1B（PTP1B）抑制活性，IC50值在4.9至14.9μg/ml之间。
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