Koh Shizuka, Maeda Naoyuki, Hirohara Yoko, Mihashi Toshifumi, Ninomiya Sayuri, Bessho Kenichiro, Watanabe Hitoshi, Fujikado Takashi, Tano Yasuo
Department of Ophthalmology, Osaka University Medical School, Suita, Japan.
Invest Ophthalmol Vis Sci. 2006 Aug;47(8):3318-24. doi: 10.1167/iovs.06-0018.
To investigate sequential changes in the optical quality of normal eyes associated with blinking.
Ocular higher-order aberrations (HOAs) were measured sequentially by using a wavefront sensor for 30 seconds in 20 eyes of 20 normal subjects. During the measurement, subjects were forced to blink every 10 seconds. The obtained aberration data were analyzed in the central 4-mm diameter for coma-like, spherical-like, and total HOAs up to the sixth-order Zernike polynomials.
The serial changes in the HOAs with blinking were classified into four groups by pattern: stable (25%), small-fluctuation (45%), sawtooth (20%), and others (10%). In the subjects with the sawtooth pattern, the total HOAs increased significantly (P < 0.001, one-way repeated-measures ANOVA) with time between blinks. Increased total HOAs and coma-like aberrations in the subjects with the sawtooth pattern suggested that the inferosuperior asymmetric change in tear film thickness is responsible.
Dynamic changes in HOAs after blinking showed variations even in clinically normal subjects. Serial measurements of HOAs may be useful in evaluating the dynamic changes in tear film and the effects on the quality of vision after blinking.
研究正常眼睛眨眼相关的光学质量的连续变化。
使用波前传感器对20名正常受试者的20只眼睛连续测量30秒高阶像差（HOAs）。测量期间，受试者每10秒被迫眨眼一次。对获得的像差数据在直径4毫米的中心区域进行分析，以研究高达六阶泽尼克多项式的类彗差、类球差和总高阶像差。
眨眼时高阶像差的连续变化按模式分为四组：稳定型（25%）、小波动型（45%）、锯齿型（20%）和其他型（10%）。在锯齿型受试者中，眨眼间隔期间总高阶像差随时间显著增加（P < 0.001，单因素重复测量方差分析）。锯齿型受试者总高阶像差和类彗差增加表明，泪膜厚度的上下不对称变化是原因所在。
即使在临床正常受试者中，眨眼后高阶像差的动态变化也存在差异。高阶像差的连续测量可能有助于评估泪膜的动态变化以及眨眼后对视觉质量的影响。
