Koh Shizuka, Maeda Naoyuki, Hirohara Yoko, Mihashi Toshifumi, Bessho Kenichiro, Hori Yuichi, Inoue Tomoyuki, Watanabe Hitoshi, Fujikado Takashi, Tano Yasuo
Department of Ophthalmology, Osaka University Medical School, Suita, Japan.
Invest Ophthalmol Vis Sci. 2008 Jan;49(1):133-8. doi: 10.1167/iovs.07-0762.
To study the sequential postblink changes in ocular higher-order aberrations (HOAs) in patients with dry eye.
A wavefront sensor was used to measure HOAs sequentially for 30 seconds in 20 eyes of 20 patients with dry eye. The 20 eyes were classified into two groups, with or without superficial punctate keratopathy (SPK) in the central cornea. During the measurement, subjects were required to blink every 10 seconds. The aberration data were analyzed in the central 4-mm diameter for coma-like, spherical-like, and total HOAs up to sixth-order Zernike polynomials. Total HOAs, as well as fluctuation index (FI) and stability index (SI) of the total HOAs over time were compared between the two groups. The sequential changes in coma-like aberration, spherical-like aberration, and total HOAs were also investigated.
The total ocular HOAs were significantly (P = 0.001) greater in dry eyes with central SPK than in dry eyes without central SPK. The sequential pattern of the total ocular HOAs had higher initial and consistently higher values in dry eyes with central SPK, whereas that of dry eyes without central SPK showed consistently lower total HOAs that were similar to the pattern of normal eyes.
Increased HOAs in dry eye at least partially result from SPK above the optical zone. The low tear volume in dry eye may not cause sequential increases in HOAs after blinking. Sequential measurement of HOAs may be useful for evaluating the sequential changes in optical quality in patients with dry eye.
研究干眼患者眨眼后眼部高阶像差（HOAs）的连续变化。
使用波前传感器对20例干眼患者的20只眼睛连续30秒测量HOAs。将这20只眼睛分为两组，中央角膜有或无浅层点状角膜病变（SPK）。测量过程中，受试者需每10秒眨眼一次。对中央直径4毫米区域内高达六阶泽尼克多项式的类彗差、类球差和总HOAs的像差数据进行分析。比较两组之间的总HOAs以及总HOAs随时间的波动指数（FI）和稳定性指数（SI）。还研究了类彗差、类球差和总HOAs的连续变化。
中央有SPK的干眼患者的眼部总HOAs显著（P = 0.001）高于中央无SPK的干眼患者。中央有SPK的干眼患者的眼部总HOAs的连续模式具有较高的初始值且始终较高，而中央无SPK的干眼患者的模式显示总HOAs始终较低，与正常眼睛的模式相似。
干眼患者HOAs增加至少部分是由光学区上方的SPK引起的。干眼患者泪液量低可能不会导致眨眼后HOAs的连续增加。HOAs的连续测量可能有助于评估干眼患者光学质量的连续变化。
