Jayakumar R, Selvamurugan N, Nair S V, Tokura S, Tamura H
Amrita Center for Nanosciences, Amrita Institute of Medical Sciences and Research Centre, Amrita Viswa Vidyapeetham University, Kochi 682026, India.
Int J Biol Macromol. 2008 Oct 1;43(3):221-5. doi: 10.1016/j.ijbiomac.2008.07.004. Epub 2008 Jul 9.
Biomaterials such as chitin, chitosan and their derivatives have a significant and rapid development in recent years. Chitin and chitosan have become cynosure of all party because of an unusual combination of biological activities plus mechanical and physical properties. However, the applications of chitin and chitosan are limited due to its insolubility in most of the solvents. The chemical modification of chitin and chitosan are keen interest because of these modifications would not change the fundamental skeleton of chitin and chitosan but would keep the original physicochemical and biochemical properties. They would also bring new or improved properties. The chemical modification of chitin and chitosan by phosphorylation is expected to be biocompatible and is able to promote tissue regeneration. In view of rapidly growing interest in chitin and chitosan and their chemical modified derivatives, we are here focusing the recent developments on preparation of phosphorylated chitin and chitosan in different methods.
近年来，几丁质、壳聚糖及其衍生物等生物材料有了显著且快速的发展。几丁质和壳聚糖因其生物活性、机械性能和物理性能的独特组合而成为各方关注的焦点。然而，几丁质和壳聚糖在大多数溶剂中不溶，这限制了它们的应用。几丁质和壳聚糖的化学改性备受关注，因为这些改性不会改变几丁质和壳聚糖的基本骨架，却能保留其原有的物理化学和生物化学性质，还会带来新的或改进的性能。通过磷酸化对几丁质和壳聚糖进行化学改性有望具有生物相容性，并能够促进组织再生。鉴于对几丁质、壳聚糖及其化学改性衍生物的兴趣迅速增长，我们在此重点介绍不同方法制备磷酸化几丁质和壳聚糖的最新进展。
