Doster W, Schirmacher W, Settles M
Technische Universität München, Physik-Department E13, Federal Republic of Germany.
Biophys J. 1990 Mar;57(3):681-4. doi: 10.1016/S0006-3495(90)82588-1.
The nonexponential closed-time distributions observed for ionic channels have been explained recently by quasi-one-dimensional models of structural diffusion (Millhauser, G. L., E. E. Salpeter, and R. E. Oswald. 1988. Proc. Natl. Acad. Sci. USA. 85: 1503-1507; Condat, C. A., and J. Jäckle. 1989. Biophys. J. 55: 915-925; Levitt, D. G. 1989. Biophys. J. 55: 489-498). We generalize this treatment by allowing for more complex trajectories using percolation theory. We assume that the gating transition depends on marginally connected conformational states leading to the observed spread in time scales.
最近，离子通道观测到的非指数闭时分布已通过结构扩散的准一维模型得到解释（米尔豪泽，G.L.，E.E.萨尔彼得和R.E.奥斯瓦尔德。1988年。美国国家科学院院刊。85: 1503 - 1507；孔达特，C.A.和J.杰克勒。1989年。生物物理学杂志。55: 915 - 925；莱维特，D.G.。1989年。生物物理学杂志。55: 489 - 498）。我们通过使用渗流理论考虑更复杂的轨迹来推广这种处理方法。我们假设门控转变取决于导致观测到的时间尺度扩展的边缘连接构象状态。
