Amanlou Massoud, Beitollahi Jalil Momen, Abdollahzadeh Shervin, Tohidast-Ekrad Zahra
Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, 14155-6451, Iran.
Phytother Res. 2006 Nov;20(11):966-9. doi: 10.1002/ptr.1986.
An open, randomized, controlled study with two parallel treatment groups was done to evaluate the efficacy of a miconazole 2% gel compared with Zataria multiflora 0.1% gel applied four times daily for 2 weeks, in the treatment of Candida-associated denture stomatitis. Twenty four patients were included in the study. The efficacy variables were the colony count of Candida from the palatal mucosa and the denture surface and the erythema surface of the palatal mucosa on days 0, 7, 14, 21 and 28 after commencement of therapy. Twelve patients received miconazole gel and twelve Z. multiflora gel. The erythema surface was significantly reduced by both gels. No significant difference was seen between the two groups (p < 0.05). There was a significant reduction in the colony count of the palatal mucosa in both groups (except on days 21 and 28 in the Zataria group p = 0.07 and 0.08). Miconazole treatment reduced the number of denture colonies more efficiently than Z. multiflora except for day 21 when the efficacy of both groups was similar (p = 0.17). The results indicate that Z. multiflora gel reduced the surface erythema of the palate more efficiently than miconazole gel but did not reduce the colony count of the denture surface as efficiently as miconazole.
进行了一项开放性、随机、对照研究，设有两个平行治疗组，以评估2%咪康唑凝胶与0.1%百里香凝胶每日4次、连续应用2周治疗念珠菌相关性义齿性口炎的疗效。24例患者纳入该研究。疗效变量为治疗开始后第0、7、14、21和28天腭黏膜和义齿表面念珠菌菌落计数以及腭黏膜红斑面积。12例患者接受咪康唑凝胶治疗，12例接受百里香凝胶治疗。两种凝胶均使红斑面积显著减小。两组之间未见显著差异（p<0.05）。两组腭黏膜菌落计数均显著降低（百里香组第21天和28天除外，p=0.07和0.08）。除第21天两组疗效相似（p=0.17）外，咪康唑治疗比百里香更有效地减少义齿菌落数量。结果表明，百里香凝胶比咪康唑凝胶更有效地减轻腭部表面红斑，但在减少义齿表面菌落计数方面不如咪康唑有效。
