不同治疗方法对义齿性口炎疗效的评估：一项随机临床研究。

Evaluation of different treatment methods against denture stomatitis: a randomized clinical study.

作者信息

Tay Lidia Yileng, Jorge Janaina Habib, Herrera Daniel Rodrigo, Campanha Nara Hellen, Gomes Brenda Paula, Andre Dos Santos Fabio

机构信息

Department of Dentistry, Ponta Grossa State University (UEPG), Ponta Grossa, Paraná, Brazil.

Department of Dental Materials and Prosthodontics, Araraquara Dental School, UNESP - Univ. Estadual Paulista, Araraquara, São Paulo, Brazil.

出版信息

Oral Surg Oral Med Oral Pathol Oral Radiol. 2014 Jul;118(1):72-7. doi: 10.1016/j.oooo.2014.03.017. Epub 2014 Apr 5.

DOI:10.1016/j.oooo.2014.03.017

PMID:24908596

Abstract

OBJECTIVE

The aim of this clinical study was to determine the efficacy of Uncaria tomentosa (cat's claw) against denture stomatitis (DS).

STUDY DESIGN

Fifty patients with DS were randomly assigned into 3 groups to receive 2% miconazole, placebo, or 2% U tomentosa gel. DS level was recorded immediately, after 1 week of treatment, and 1 week after treatment. The clinical effectiveness of each treatment was measured using Newton's criteria. Mycologic samples from palatal mucosa and prosthesis were obtained to determinate colony forming units per milliliter (CFU/mL) and fungal identification at each evaluation period.

RESULTS

Candida species were identified with HiCrome Candida and API 20C AUX biochemical test. DS severity decreased in all groups (P < .05). A significant reduction in number of CFU/mL after 1 week (P < .05) was observed for all groups and remained after 14 days (P > .05). C albicans was the most prevalent microorganism before treatment, followed by C tropicalis, C glabrata, and C krusei, regardless of the group and time evaluated. U tomentosa gel had the same effect as 2% miconazole gel.

CONCLUSIONS

U tomentosa gel is an effective topical adjuvant treatment for denture stomatitis.

摘要

目的

本临床研究旨在确定绒毛钩藤（猫爪草）对义齿性口炎（DS）的疗效。

研究设计

50例DS患者被随机分为3组，分别接受2%咪康唑、安慰剂或2%绒毛钩藤凝胶治疗。在治疗前、治疗1周后和治疗后1周记录DS水平。采用牛顿标准衡量每种治疗方法的临床疗效。在每个评估期采集腭黏膜和义齿的真菌样本，以确定每毫升菌落形成单位（CFU/mL）并进行真菌鉴定。

结果

通过HiCrome念珠菌鉴定和API 20C AUX生化试验鉴定念珠菌种类。所有组的DS严重程度均降低（P < 0.05）。所有组在1周后CFU/mL数量均显著减少（P < 0.05），并在14天后保持（P > 0.05）。无论评估的组和时间如何，白色念珠菌是治疗前最常见的微生物，其次是热带念珠菌、光滑念珠菌和克柔念珠菌。绒毛钩藤凝胶与2%咪康唑凝胶效果相同。