Toyokuni Shinya
Department of Pathology and Biology of Diseases, Graduate School of Medicine, Kyoto University, Japan.
Antioxid Redox Signal. 2006 Jul-Aug;8(7-8):1373-7. doi: 10.1089/ars.2006.8.1373.
Oxidative stress is associated with carcinogenesis. Reactive oxygen and nitrogen species contribute to the accumulation of mutations in the genome, presumably followed by selective processes. Recent data suggest that preferred signaling pathways exist for oxidative stress-associated carcinogenesis. Whether this completely depends on random mutations induced by reactive species or whether instead some fragile genomic loci are sensitive to oxidative damage in association with changes of transcriptional activity or other topologic or nontopologic effects remains to be explored. Reliable markers for oxidative stress as well as for oxidative stress-induced preneoplastic lesions must be established.
氧化应激与致癌作用相关。活性氧和氮物种导致基因组中突变的积累，大概随后会发生选择过程。最近的数据表明，存在与氧化应激相关致癌作用的优选信号通路。这是否完全取决于活性物种诱导的随机突变，或者相反，某些脆弱的基因组位点是否与转录活性变化或其他拓扑或非拓扑效应相关而对氧化损伤敏感，仍有待探索。必须建立氧化应激以及氧化应激诱导的癌前病变的可靠标志物。
