Zeleniuch-Jacquotte Anne, Lundin Eva, Micheli Andrea, Koenig Karen L, Lenner Per, Muti Paola, Shore Roy E, Johansson Ingegerd, Krogh Vittorio, Lukanova Annekatrin, Stattin Pär, Afanasyeva Yelena, Rinaldi Sabina, Arslan Alan A, Kaaks Rudolf, Berrino Franco, Hallmans Göran, Toniolo Paolo, Adlercreutz Herman
Department of Environmental Medicine, New York University School of Medicine, New York, NY 10016-3240, USA.
Int J Cancer. 2006 Nov 15;119(10):2376-81. doi: 10.1002/ijc.22140.
It has been suggested that phytoestrogens protect against hormone-dependent cancers. Lignans are the main class of phytoestrogens in Western diets. We conducted a prospective study of endometrial cancer and circulating levels of the main human lignan, enterolactone. The design was a case-control study nested within 3 prospective cohort studies, in New York, Sweden and Italy. Serum or plasma samples had been collected at enrollment and stored at -80 degrees C. A total of 153 cases, diagnosed a median of 5.3 years after blood donation, and 271 matched controls were included. No difference in circulating enterolactone was observed between cases (median, 19.2 nmol/L) and controls (18.5 nmol/L). Adjusting for body mass index, the odds ratio for the top tertile of enterolactone, as compared to the lowest was 1.2 (95% CI, 0.7-2.0; p for trend = 0.53). Lack of association was observed in both pre- and postmenopausal women. No correlation was observed between enterolactone and circulating estrogens or SHBG in healthy postmenopausal women. These results do not support a protective role of circulating lignans, in the range of levels observed, against endometrial cancer.
有人提出，植物雌激素可预防激素依赖性癌症。木脂素是西方饮食中主要的植物雌激素类别。我们对子宫内膜癌与主要人体木脂素肠内酯的循环水平进行了一项前瞻性研究。该研究设计为嵌套于纽约、瑞典和意大利的3项前瞻性队列研究中的病例对照研究。在入组时采集了血清或血浆样本，并储存在-80摄氏度。共纳入了153例病例（在献血后中位5.3年被诊断）和271例匹配对照。病例组（中位值为19.2 nmol/L）与对照组（18.5 nmol/L）的循环肠内酯未观察到差异。调整体重指数后，肠内酯最高三分位数与最低三分位数相比的比值比为1.2（95%可信区间，0.7 - 2.0；趋势p值 = 0.53）。绝经前和绝经后女性均未观察到相关性。在健康绝经后女性中，未观察到肠内酯与循环雌激素或性激素结合球蛋白之间的相关性。这些结果不支持在所观察到的水平范围内循环木脂素对子宫内膜癌具有保护作用。
