Kilkkinen Annamari, Virtamo Jarmo, Vartiainen Erkki, Sankila Risto, Virtanen Mikko J, Adlercreutz Herman, Pietinen Pirjo
Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland.
Int J Cancer. 2004 Jan 10;108(2):277-80. doi: 10.1002/ijc.11519.
The lignan enterolactone produced by the intestinal microflora from dietary precursors has been hypothesized to protect against hormone-dependent cancers. We conducted a nested case-control study to examine the relationship between serum enterolactone concentration and risk of breast cancer. Enterolactone concentrations were measured by time-resolved fluoroimmunoassay in serum collected at 4 independent cross-sectional population surveys from 206 women with breast cancer diagnosed during follow-up (mean 8.0 years) and from 215 controls frequency-matched to cases by study cohort, 5-year age group and study area. Mean serum enterolactone concentration (nmol/l) did not significantly differ between case and control subjects [25.2 (SD 22.2) vs. 24.0 (SD 21.3), respectively]. Odds ratios for breast cancer risk estimated by conditional logistic regression for increasing concentration of enterolactone in quartiles were 1.00 (referent), 1.67 (95% CI 0.95-2.95), 1.71 (95% CI 0.96-3.06) and 1.30 (95% CI 0.73-2.31), and p for trend was 0.48. Our findings do not support the hypothesis that high serum enterolactone concentration is associated with reduced risk of breast cancer.
肠道微生物群利用膳食前体产生的木脂素肠内酯被认为可以预防激素依赖性癌症。我们进行了一项巢式病例对照研究，以检验血清肠内酯浓度与乳腺癌风险之间的关系。在4次独立的横断面人群调查中收集的血清中，通过时间分辨荧光免疫测定法测量肠内酯浓度，这些血清来自随访期间确诊为乳腺癌的206名女性（平均8.0年）以及215名对照，对照按研究队列、5岁年龄组和研究地区与病例进行频率匹配。病例组和对照组受试者的血清肠内酯平均浓度（nmol/l）无显著差异[分别为25.2（标准差22.2）和24.0（标准差21.3）]。通过条件逻辑回归估计的四分位数中肠内酯浓度增加时乳腺癌风险的比值比分别为1.00（参照）、1.67（95%可信区间0.95 - 2.95）、1.71（95%可信区间0.96 - 3.06）和1.30（95%可信区间0.73 - 2.31），趋势p值为0.48。我们的研究结果不支持高血清肠内酯浓度与降低乳腺癌风险相关的假设。
