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肌痛性脑脊髓炎/慢性疲劳综合征患儿的特殊问题及肠道病毒关联。

Special problems of children with myalgic encephalomyelitis/chronic fatigue syndrome and the enteroviral link.

作者信息

Colby J

机构信息

The Young ME Sufferers (Tymes) Trust, Ingatestone, Essex, UK.

出版信息

J Clin Pathol. 2007 Feb;60(2):125-8. doi: 10.1136/jcp.2006.042606. Epub 2006 Aug 25.

Abstract

Since 1997, it has been known that myalgic encephalomyelitis/chronic fatigue syndrome constitutes the biggest cause of long-term sickness leading to absence from school, in both staff and pupils. The scale of the problem in children is substantial, and the pattern of illness in schools suggests a prominent role for viral infection--for example, the clustering of cases. The Dowsett-Colby study of 1997, researching long-term sickness, reported on a school roll of 333,024 pupils and 27,327 staff, and found a prevalence of long-term sickness in 70 of 100,000 pupils and 500 of 100,000 staff; 39% of cases were in clusters of three or more. The peak age was 14-16 years. The illness is known to be potentially severe and chronic. In addition, the Tymes Trust has reported that many affected children struggle for recognition of their needs, and are bullied by medical and educational professionals. Children should have time to recover sufficiently before returning to school; sustainable, energy-efficient and often home-based education is important here to fulfil legal obligations. Research is needed on viruses that trigger childhood myalgic encephalomyelitis--for example, enteroviruses--and on the neurocognitive defects caused by myalgic encephalomyelitis. We should recognise the value of previous biological research and records of outbreaks, and I recommend that myalgic encephalomyelitis be made notifiable owing to the encephalitic nature of the effects commonly reported in this illness.

摘要

自1997年以来,人们就已经知道,肌痛性脑脊髓炎/慢性疲劳综合征是导致教职员工和学生长期患病并缺课的最大原因。儿童中这一问题的规模相当大,学校中的发病模式表明病毒感染起到了突出作用——例如,病例呈聚集性。1997年道塞特-科尔比关于长期患病的研究,对333,024名学生和27,327名教职员工的学校名单进行了调查,发现每10万名学生中有70人、每10万名教职员工中有500人患有长期疾病;39%的病例是三人或三人以上的聚集性病例。发病高峰年龄为14至16岁。已知这种疾病可能严重且呈慢性。此外,泰姆斯信托基金报告称,许多受影响的儿童难以让自己的需求得到认可,还受到医疗和教育专业人员的欺凌。儿童在返校前应有足够的时间康复;在这里,可持续、节能且通常以家庭为基础的教育对于履行法律义务很重要。需要对引发儿童肌痛性脑脊髓炎的病毒——例如肠道病毒——以及肌痛性脑脊髓炎引起的神经认知缺陷进行研究。我们应该认识到以往生物学研究和疫情记录的价值,并且我建议鉴于这种疾病通常报告的症状具有脑炎性质,应将肌痛性脑脊髓炎列为须上报的疾病。

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