来自一只易患狼疮小鼠的免疫球蛋白轻链在正常小鼠中诱导自身抗体产生。
An immunoglobulin light chain from a lupus-prone mouse induces autoantibodies in normal mice.
作者信息
Puccetti A, Koizumi T, Migliorini P, André-Schwartz J, Barrett K J, Schwartz R S
机构信息
Department of Medicine, Tufts University School of Medicine, Boston, MA 02111.
出版信息
J Exp Med. 1990 Jun 1;171(6):1919-30. doi: 10.1084/jem.171.6.1919.
Abstract
Autoantibodies against the 70-kD U1 RNP nucleoprotein autoantigen and DNA were elicited in normal BALB/c mice with a purified Ig light chain. This light chain, derived from a lupus-prone MRL-lpr/lpr mouse, has two distinctive properties: it contains an idiotypic marker recognized by a monoclonal MRL-lpr/lpr anti-snRNP autoantibody, and the amino acid sequence of its third hypervariable region (CDR3) is homologous to a sequence in an antigenic region of the 70-kD U1 RNP polypeptide. The results demonstrate that an Ig idiotype that mimics an autoantigen can induce autoimmunization.
摘要
用纯化的Ig轻链在正常BALB/c小鼠中诱发了针对70-kD U1 RNP核蛋白自身抗原和DNA的自身抗体。这种轻链源自易患狼疮的MRL-lpr/lpr小鼠，具有两个独特的特性：它含有一个由单克隆MRL-lpr/lpr抗snRNP自身抗体识别的独特型标记，并且其第三个高变区（CDR3）的氨基酸序列与70-kD U1 RNP多肽抗原区域中的一个序列同源。结果表明，模拟自身抗原的Ig独特型可诱导自身免疫。
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