Perezous Leticia F, Stevenson Gene C, Flaitz Catherine M, Goldschmidt Millicent E, Engelmeier Robert L, Nichols C Mark
Department of Prosthodontics, University of Texas - Dental Branch, Houston, TX 77030, USA.
J Prosthodont. 2006 Sep-Oct;15(5):306-15. doi: 10.1111/j.1532-849X.2006.00127.x.
This in vivo investigation compared the oral candidal population between heat-cured acrylic resin and nickel-chromium-beryllium alloy in maxillary complete dentures in HIV-infected patients.
Split-palate maxillary complete dentures were fabricated for 19 HIV-infected patients: one-half of the palate was made in acrylic resin and the other half in nickel-chromium-beryllium. Patients were divided into low or high CD4+ lymphocyte count groups. Dentures were worn for 5 months. Palatal mucosa was clinically evaluated at baseline, 1, 3, and 5 months after denture insertion. Specimens were collected at 1, 3, and 5 months using a modified imprint culture method. Speciation of Candida was performed using a chromogenic culture medium. Two-sample t-test was employed to determine effects and significant interactions between the control and test groups and the low and high CD4+ lymphocyte groups. A chi(2) test analyzed and compared the results of the clinical evaluation (p < 0.05).
Significant differences were observed in the colony counts between both materials during the third (p= 0.046) and fifth months (p= 0.039). The low CD4+ group demonstrated significant differences during the third (p= 0.03) and fifth months (p= 0.05). There were no significant differences between the species of Candida that colonized either material with the exception of Candida dubliniensis (p < 0.001) and "Others" (p < 0.001) during the first and fifth months. There were no significant differences on the clinical appearance of the palatal mucosa between both materials (p= 1.00).
The metal base proved to be effective in decreasing the fungal growth typically present in complete dentures. Although overt clinical manifestations were not present, colony counts of Candida species were high in the acrylic resin denture bases of these patients. This investigation demonstrated that metal base complete dentures provide an important alternative dental service for edentulous HIV-positive and other patients who are particularly prone to higher incidences of fungal infections.
本体内研究比较了热固化丙烯酸树脂和镍铬铍合金制作的上颌全口义齿在HIV感染患者口腔内念珠菌的数量。
为19名HIV感染患者制作了腭裂上颌全口义齿：腭部的一半用丙烯酸树脂制作，另一半用镍铬铍合金制作。患者被分为CD4+淋巴细胞计数低或高的组。义齿佩戴5个月。在义齿插入后的基线、1、3和5个月对腭黏膜进行临床评估。在1、3和5个月时使用改良的印迹培养法收集标本。使用显色培养基对念珠菌进行菌种鉴定。采用两样本t检验来确定对照组和试验组以及CD4+淋巴细胞计数低和高的组之间的效应和显著相互作用。采用卡方检验分析和比较临床评估结果（p<0.05）。
在第三个月（p=0.046）和第五个月（p=0.039）时，观察到两种材料的菌落计数存在显著差异。CD4+计数低的组在第三个月（p=0.03）和第五个月（p=0.05）时表现出显著差异。除了在第一个月和第五个月期间都柏林念珠菌（p<0.001）和“其他菌种”（p<0.001）外，在两种材料上定植的念珠菌菌种之间没有显著差异。两种材料在腭黏膜的临床表现上没有显著差异（p=1.00）。
金属基托被证明能有效减少全口义齿中常见的真菌生长。尽管没有明显的临床表现，但这些患者的丙烯酸树脂义齿基托中念珠菌的菌落计数很高。这项研究表明，金属基托全口义齿为无牙的HIV阳性患者和其他特别容易发生真菌感染的患者提供了一种重要的替代牙科服务。
