Kim Sung-wan, Shin Il-seon, Kim Jae-min, Kang Ho-cheol, Mun Ji-ung, Yang Su-jin, Yoon Jin-sang
Department of Psychiatry, Chonnam National Univ. Hospital, 8 Hak-dong, Dong-ku, Kwangju 501-757, Republic of Korea.
Psychosomatics. 2006 Sep-Oct;47(5):440-2. doi: 10.1176/appi.psy.47.5.440.
Gastroparesis is a condition of abnormal gastric motility characterized by delayed gastric emptying without evidence of mechanical outlet obstruction. The authors describe complete remission of recurrent postprandial discomfort, nausea, and vomiting within 1 week of starting mirtazapine in a gastroparetic patient who had failed to respond, in 7 months, to conventional prokinetics (erythromycin, metoclopramide, domperidone, perphenazine, itopride, bethanechol, and/or tegaserod) and pyloric injection of botulinum toxin. This is the first report to show that mirtazapine may be an effective alternative when gastroparesis is refractory to conventional measures.
胃轻瘫是一种胃动力异常的病症，其特征为胃排空延迟，且无机械性出口梗阻的证据。作者描述了一名胃轻瘫患者在开始服用米氮平1周内，复发性餐后不适、恶心和呕吐完全缓解。该患者在7个月内对传统促动力药（红霉素、甲氧氯普胺、多潘立酮、奋乃静、伊托必利、氨甲酰甲胆碱和/或替加色罗）以及幽门注射肉毒杆菌毒素均无反应。这是首份表明当胃轻瘫对传统治疗措施无效时，米氮平可能是一种有效替代药物的报告。
