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关于血管消退的新见解。

New insights regarding vessel regression.

作者信息

Im Eunok, Kazlauskas Andrius

机构信息

Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts 02114, USA.

出版信息

Cell Cycle. 2006 Sep;5(18):2057-9. doi: 10.4161/cc.5.18.3210. Epub 2006 Sep 15.

DOI:10.4161/cc.5.18.3210
PMID:16969103
Abstract

The regression of blood vessels is an intrinsic feature of both physiological and pathological processes. This suggests the existence of molecular regulators of regression, which would be potential targets for management and therapy of numerous diseases involving angiogenesis. This review summarizes some of the prevailing views on vessel regression and highlights our recent contribution to the field.

摘要

血管消退是生理和病理过程的一个内在特征。这表明存在消退的分子调节因子,它们可能是治疗众多涉及血管生成疾病的潜在靶点。这篇综述总结了一些关于血管消退的主流观点,并突出了我们近期在该领域的贡献。

相似文献

1
New insights regarding vessel regression.关于血管消退的新见解。
Cell Cycle. 2006 Sep;5(18):2057-9. doi: 10.4161/cc.5.18.3210. Epub 2006 Sep 15.
2
Basic and therapeutic aspects of angiogenesis.血管生成的基础与治疗方面。
Cell. 2011 Sep 16;146(6):873-87. doi: 10.1016/j.cell.2011.08.039.
3
[Angiogenesis - possibilities, problems and perspectives].[血管生成——可能性、问题与前景]
Postepy Biochem. 2015;61(1):25-34.
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VEGF-A: a critical regulator of blood vessel growth.VEGF-A:血管生长的关键调节因子。
Eur Cytokine Netw. 2009 Dec;20(4):158-63. doi: 10.1684/ecn.2009.0170.
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Recent advances in angiogenesis, anti-angiogenesis and vascular targeting.血管生成、抗血管生成及血管靶向治疗的最新进展
Trends Pharmacol Sci. 2002 Dec;23(12):576-82. doi: 10.1016/s0165-6147(02)02109-0.
6
Molecular mechanisms and clinical applications of angiogenesis.血管生成的分子机制与临床应用。
Nature. 2011 May 19;473(7347):298-307. doi: 10.1038/nature10144.
7
Vascular endothelial growth factor and its receptors.血管内皮生长因子及其受体。
Cytokine Growth Factor Rev. 1996 Oct;7(3):259-70. doi: 10.1016/s1359-6101(96)00027-5.
8
[MOLECULAR AND CELLULAR MECHANISMS OF ANGIOGENESIS IN PHYSIOLOGICAL AND PATHOLOGICAL CONDITIONS].[生理和病理条件下血管生成的分子和细胞机制]
Ross Fiziol Zh Im I M Sechenova. 2017 Feb;103(2):121-37.
9
The role of adrenomedullin in angiogenesis.肾上腺髓质素在血管生成中的作用。
Peptides. 2005 Sep;26(9):1670-5. doi: 10.1016/j.peptides.2005.02.017. Epub 2005 Mar 17.
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The vascular endothelial growth factor family; proteins which guide the development of the vasculature.血管内皮生长因子家族;引导脉管系统发育的蛋白质。
Int J Exp Pathol. 1998 Oct;79(5):255-65. doi: 10.1046/j.1365-2613.1998.700404.x.

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The bipartite rac1 Guanine nucleotide exchange factor engulfment and cell motility 1/dedicator of cytokinesis 180 (elmo1/dock180) protects endothelial cells from apoptosis in blood vessel development.二分体Rac1鸟嘌呤核苷酸交换因子吞噬和细胞运动蛋白1/胞质分裂 dedicator 180(ELMO1/DOCK180)在血管发育中保护内皮细胞免于凋亡。
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Chemokines and Their Receptors Are Key Players in the Orchestra That Regulates Wound Healing.
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PLoS One. 2013 Sep 27;8(9):e76078. doi: 10.1371/journal.pone.0076078. eCollection 2013.
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Domains I and IV of annexin A2 affect the formation and integrity of in vitro capillary-like networks. annexin A2 的结构域 I 和 IV 影响体外毛细血管样网络的形成和完整性。
PLoS One. 2013;8(3):e60281. doi: 10.1371/journal.pone.0060281. Epub 2013 Mar 29.
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Regression activity that is naturally present in vitreous becomes ineffective as patients develop proliferative diabetic retinopathy.玻璃体内自然存在的视网膜再血管化活动会随着患者发生增生性糖尿病视网膜病变而失效。
Diabetologia. 2013 Jun;56(6):1444-53. doi: 10.1007/s00125-013-2884-2. Epub 2013 Mar 19.
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MT-MMPS as Regulators of Vessel Stability Associated with Angiogenesis.基质金属蛋白酶-膜型金属蛋白酶作为与血管生成相关的血管稳定性调节剂。
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Phospholipase Cgamma activation drives increased production of autotaxin in endothelial cells and lysophosphatidic acid-dependent regression.PLCγ 激活驱动内皮细胞中自分泌运动因子的产生增加和溶脂酸依赖性的退化。
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PDGF/VEGF system activation and angiogenesis following initial post ovariectomy meningeal microvessel loss.卵巢切除术后初期脑膜微血管丢失后的血小板源性生长因子/血管内皮生长因子系统激活与血管生成
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