Klagsbrun M, D'Amore P A
Department of Surgery, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Cytokine Growth Factor Rev. 1996 Oct;7(3):259-70. doi: 10.1016/s1359-6101(96)00027-5.
Vascular endothelial growth factor (VEGF) is a prime regulator of endothelial cell proliferation, angiogenesis, vasculogenesis and vascular permeability. Its activity is mediated by the high affinity tyrosine kinase receptors, KDR/Fik-1 and Fit-1. In this article, recently discovered structural, molecular and biological properties of VEGF are described. Among the topics discussed are VEGF and VEGF receptor structure and bioactivity, the regulation of VEGF expression, the role of VEGF and its receptors in vascular development, and the involvement of VEGF and its receptors in normal and pathological (ocular and tumor) angiogenesis.
血管内皮生长因子（VEGF）是内皮细胞增殖、血管生成、血管发生和血管通透性的主要调节因子。其活性由高亲和力酪氨酸激酶受体KDR/Fik-1和Fit-1介导。本文描述了VEGF最近发现的结构、分子和生物学特性。讨论的主题包括VEGF和VEGF受体的结构与生物活性、VEGF表达的调节、VEGF及其受体在血管发育中的作用，以及VEGF及其受体在正常和病理性（眼部和肿瘤）血管生成中的参与情况。
