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商业化人乳头瘤病毒（HPV）基因分型检测的初步研究：HPV风险组与细胞学和组织学的比较

Pilot study of a commercialized human papillomavirus (HPV) genotyping assay: comparison of HPV risk group to cytology and histology.

作者信息

Castle Philip E, Sadorra Mark, Garcia Francisco, Holladay E Blair, Kornegay Janet

机构信息

Division of Cancer Epidemiology, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892-7234, USA.

出版信息

J Clin Microbiol. 2006 Nov;44(11):3915-7. doi: 10.1128/JCM.01305-06. Epub 2006 Sep 13.

DOI:10.1128/JCM.01305-06
PMID:16971652
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1698309/
Abstract

We evaluated a commercialized PCR assay, Linear Array, that detects 37 human papillomavirus (HPV) genotypes, using a sample of liquid cytology specimens (n = 534). We found a strong association of an increasing level of HPV risk (HPV type 16 [HPV16] > HPV18 > other carcinogenic types > noncarcinogenic types > negative specimens) with increasing severities of cytologic interpretations (P(Trend) < 0.0005) and histologic diagnoses (P(Trend) < 0.0005).

摘要

我们使用一份液基细胞学标本样本（n = 534），对一种商业化的聚合酶链反应（PCR）检测方法——线性阵列法进行了评估，该方法可检测37种人乳头瘤病毒（HPV）基因型。我们发现，HPV风险水平升高（HPV 16型[HPV16] > HPV18型 > 其他致癌型 > 非致癌型 > 阴性标本）与细胞学判读严重程度增加（P（趋势）< 0.0005）及组织学诊断严重程度增加（P（趋势）< 0.0005）之间存在强烈关联。

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A comparison of a prototype PCR assay and hybrid capture 2 for detection of carcinogenic human papillomavirus DNA in women with equivocal or mildly abnormal papanicolaou smears.对原型聚合酶链反应检测法和杂交捕获2法在巴氏涂片结果不明确或轻度异常的女性中检测致癌性人乳头瘤病毒DNA的比较。
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Worldwide distribution of human papillomavirus types in cytologically normal women in the International Agency for Research on Cancer HPV prevalence surveys: a pooled analysis.国际癌症研究机构人乳头瘤病毒流行率调查中细胞学正常女性人乳头瘤病毒类型的全球分布：一项汇总分析
Lancet. 2005;366(9490):991-8. doi: 10.1016/S0140-6736(05)67069-9.
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The elevated 10-year risk of cervical precancer and cancer in women with human papillomavirus (HPV) type 16 or 18 and the possible utility of type-specific HPV testing in clinical practice.16或18型人乳头瘤病毒（HPV）感染女性发生宫颈上皮内瘤变和宫颈癌的10年风险升高以及型特异性HPV检测在临床实践中的潜在应用价值
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