DNA聚合酶IV在大肠杆菌SOS诱变活性中的作用。
Role of DNA polymerase IV in Escherichia coli SOS mutator activity.
作者信息
Kuban Wojciech, Banach-Orlowska Magdalena, Schaaper Roel M, Jonczyk Piotr, Fijalkowska Iwona J
机构信息
Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawinskiego 5A, 02 106 Warsaw, Poland.
出版信息
J Bacteriol. 2006 Nov;188(22):7977-80. doi: 10.1128/JB.01088-06. Epub 2006 Sep 15.
Abstract
Constitutive expression of the SOS regulon in Escherichia coli recA730 strains leads to a mutator phenotype (SOS mutator) that is dependent on DNA polymerase V (umuDC gene product). Here we show that a significant fraction of this effect also requires DNA polymerase IV (dinB gene product).
摘要
大肠杆菌recA730菌株中SOS调节子的组成型表达导致一种依赖于DNA聚合酶V（umuDC基因产物）的突变表型（SOS突变体）。在此我们表明，这种效应的很大一部分还需要DNA聚合酶IV（dinB基因产物）。
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A single amino acid governs enhanced activity of DinB DNA polymerases on damaged templates.单个氨基酸决定了DinB DNA聚合酶在受损模板上的增强活性。
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Mutator phenotype resulting from DNA polymerase IV overproduction in Escherichia coli: preferential mutagenesis on the lagging strand.大肠杆菌中DNA聚合酶IV过量产生导致的突变体表型：滞后链上的优先诱变。
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