Zhang J, Chen J D Z
Veterans Research and Education Foundation, VA Medical Center, Oklahoma City, OK, USA.
Aliment Pharmacol Ther. 2006 Oct 1;24(7):991-1002. doi: 10.1111/j.1365-2036.2006.03087.x.
Over the past 20 years, gastric electrical stimulation has received increasing attention among researchers and clinicians.
To give a systematic review on the effects, mechanisms and applications of gastric electrical stimulation.
Medline was used to identify the articles to be included in this review. Key words used for the search included gastric electrical stimulation, gastric pacing, electrical stimulation, stomach, gastrointestinal motility, central nervous system, gastroparesis, nausea and vomiting; obesity and weight loss. Combinational uses of these keywords were made to identify relevant articles. Most of the articles included in this review ranged from 1985 to 2006.
Based on the general search, the review was structured as follows: (i) peripheral and central effects and mechanisms of gastric electrical stimulation; (ii) clinical applications of gastric electrical stimulation for gastroparesis and obesity and (iii) future development of gastric electrical stimulation.
Great progress has been made during the past decades. Gastric electrical stimulation has been shown to be effective in normalizing gastric dysrhythmia, accelerating gastric emptying and improving nausea and vomiting. Implantable device has been made available for treating gastroparesis as well as obesity. However, development of a new device and controlled clinical studies are required to further prove clinical efficacy of gastric electrical stimulation.
在过去20年中，胃电刺激在研究者和临床医生中受到越来越多的关注。
对胃电刺激的作用、机制及应用进行系统综述。
使用Medline检索纳入本综述的文章。检索所用关键词包括胃电刺激、胃起搏、电刺激、胃、胃肠动力、中枢神经系统、胃轻瘫、恶心和呕吐；肥胖和体重减轻。通过组合使用这些关键词来识别相关文章。本综述纳入的大多数文章发表于1985年至2006年。
基于全面检索，本综述结构如下：（i）胃电刺激的外周和中枢作用及机制；（ii）胃电刺激在胃轻瘫和肥胖症中的临床应用；（iii）胃电刺激的未来发展。
在过去几十年中已取得重大进展。胃电刺激已被证明在使胃节律失常正常化、加速胃排空以及改善恶心和呕吐方面有效。可植入装置已可用于治疗胃轻瘫和肥胖症。然而，需要开发新装置并开展对照临床研究以进一步证明胃电刺激的临床疗效。
