Oliveira C, Harizman N, Girkin C A, Xie A, Tello C, Liebmann J M, Ritch R
New York University School of Medicine, 310 East 14th Street suite 304, New York, NY 10003, USA.
Br J Ophthalmol. 2007 Jan;91(1):37-9. doi: 10.1136/bjo.2006.102061. Epub 2006 Sep 20.
To investigate the relationship between optic disc area and axial length in normal eyes of white and black people.
Consecutive eligible normal subjects were enrolled. Ocular biometry was obtained using A-scan ultrasonography, and reliable images of the optic disc were obtained using a confocal scanning laser ophthalmoscope. The relationship between optic disc area and axial length was assessed using univariate and multivariate models.
281 eyes of 281 subjects were enrolled. Black subjects (n = 157) had significantly larger discs (mean (SD) disc area, 2.12 (0.5) mm(2)) than white subjects (n = 124; 1.97 (0.6) mm(2); t test, p = 0.02). Optic disc area increased with axial length (Pearson's correlation coefficient, r = 0.13, p<0.035) for the entire study population. Multivariate regression models including race, disc area and axial length showed that a significant but weak linear relationship exists between axial length and disc area (partial correlation coefficient 0.14; p<0.024), and with race and disc area (partial correlation coefficient 0.19; p<0.017) when adjusted for the effects of other terms in the model.
Increased disc area is associated with longer axial length measurements and African ancestry. This may have implications for pathophysiology and risk assessment of glaucoma.
研究白种人和黑种人正常眼睛的视盘面积与眼轴长度之间的关系。
纳入连续符合条件的正常受试者。使用A超超声生物测量仪获取眼部生物测量数据，并使用共焦扫描激光眼底镜获取视盘的可靠图像。使用单变量和多变量模型评估视盘面积与眼轴长度之间的关系。
纳入281名受试者的281只眼睛。黑人受试者（n = 157）的视盘（平均（标准差）视盘面积，2.12（0.5）mm²）明显大于白人受试者（n = 124；1.97（0.6）mm²；t检验，p = 0.02）。在整个研究人群中，视盘面积随眼轴长度增加（Pearson相关系数，r = 0.13，p<0.035）。包括种族、视盘面积和眼轴长度的多变量回归模型显示，在调整模型中其他因素的影响后，眼轴长度与视盘面积之间存在显著但微弱的线性关系（偏相关系数0.14；p<0.024），与种族和视盘面积之间也存在这种关系（偏相关系数0.19；p<0.017）。
视盘面积增加与更长的眼轴长度测量值以及非洲血统相关。这可能对视神经病变的病理生理学和风险评估有影响。
