Nouri A M, Smith M E, Crosby D, Oliver R T
Medical Oncology, London Hospital, Whitechapel, UK.
Br J Cancer. 1990 Oct;62(4):603-6. doi: 10.1038/bjc.1990.338.
The expression of the major histocompatibility complex (MHC) class I and II antigens and lymphocyte function-associated antigen-3 (LFA-3) was investigated using immunohistochemical staining of bladder tissue sections from 18 patients with transitional cell carcinoma (TCC) and two normal bladder specimens. The expressions of HLA-A,B,C antigens varied greatly between different tumours. Complete loss was observed in one of 18 cases. Moderate to strong expression of HLA-A,B,C antigens was observed in 10 of 18 cases with the remaining seven cases showing either weak expression or expression on only a proportion of the tumour cells. Selective loss of HLA-Bw6 was seen in one of 18 cases. In many cases heterogenous and often focal expression of HLA-D products was seen. In one case tumour cells not expressing HLA-DR antigens were adjacent to strongly HLA-DR expressing non-neoplastic bladder epithelium, indicating a lack of inducible HLA-DR in the tumour cells. LFA-3 was undetectable in two of 18 cases with the remaining 16 cases showing moderate to strong expression of the molecule. These findings indicate that a substantial proportion of bladder tumours have one or more of a wide range of different alterations in the expressions of immunoregulatory molecules that could contribute to escape from immune surveillance.
利用免疫组织化学染色法，对18例移行细胞癌（TCC）患者的膀胱组织切片以及两个正常膀胱标本进行研究，以检测主要组织相容性复合体（MHC）I类和II类抗原以及淋巴细胞功能相关抗原-3（LFA-3）的表达情况。不同肿瘤之间HLA-A、B、C抗原的表达差异很大。18例中有1例出现完全缺失。18例中有10例观察到HLA-A、B、C抗原呈中度至强表达，其余7例则表现为弱表达或仅部分肿瘤细胞表达。18例中有1例出现HLA-Bw6的选择性缺失。在许多病例中，可见HLA-D产物的异质性且常为局灶性表达。有1例中，不表达HLA-DR抗原的肿瘤细胞紧邻强表达HLA-DR的非肿瘤性膀胱上皮，表明肿瘤细胞中缺乏可诱导的HLA-DR。18例中有2例未检测到LFA-3，其余16例该分子呈中度至强表达。这些发现表明，相当一部分膀胱肿瘤在免疫调节分子表达方面存在一种或多种广泛的不同改变，这可能有助于肿瘤逃避免疫监视。
