Kaleem M, Kirmani D, Asif M, Ahmed Q, Bano Bilqees
Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, India.
Indian J Exp Biol. 2006 Sep;44(9):745-8.
Oral administration of ethanol extract of N. sativa seeds (300 mg/kg body weight/day) to streptozotocin induced diabetic rats for 30 days significantly reduced the elevated levels of blood glucose, lipids, plasma insulin and improved altered levels of lipid peroxidation products (TBARS and hydroperoxides) and antioxidant enzymes like catalase, superoxide dismutase, reduced glutathione and glutathione peroxidase in liver and kidney. The results confirm the antidiabetic activity of N. sativa seeds extract and suggest that because of its antioxidant effects its administration may be useful in controlling the diabetic complications in experimental diabetic rats.
给链脲佐菌素诱导的糖尿病大鼠口服紫花苜蓿种子乙醇提取物（300毫克/千克体重/天），持续30天，可显著降低血糖、血脂、血浆胰岛素的升高水平，并改善肝脏和肾脏中脂质过氧化产物（硫代巴比妥酸反应物和氢过氧化物）以及抗氧化酶（如过氧化氢酶、超氧化物歧化酶、还原型谷胱甘肽和谷胱甘肽过氧化物酶）的改变水平。结果证实了紫花苜蓿种子提取物的抗糖尿病活性，并表明由于其抗氧化作用，给予该提取物可能有助于控制实验性糖尿病大鼠的糖尿病并发症。
