Håkansson A, Stene C, Mihaescu A, Molin G, Ahrné S, Thorlacius H, Jeppsson B
Food Hygiene, Department of Food Technology, Engineering and Nutrition, Lund University, Lund, Sweden.
Dig Dis Sci. 2006 Nov;51(11):2094-101. doi: 10.1007/s10620-006-9170-9. Epub 2006 Sep 29.
Ischaemia/reperfusion (I/R) of the colon is an inflammatory condition that leads to tissue injury where reactive oxygen species play a central role. Rose hip is rich in biologically active polyphenols with antioxidative properties, which may be important in prevention of lipid peroxidation. L. plantarum DSM 9843 possesses enzymatic activity towards polyphenols. The objective of this study was to define the effect of oral administration of L. plantarum and rose hip in I/R injury. Administration of rose hip and L. plantarum significantly decreased MDA levels in caecum tissue and Enterobacteriaceae counts in caecum stool. A positive correlation between MDA levels and Enterobacteriaceae counts was found. The results support a synergistic/additive role of rose hip and L. plantarum in reducing lipid peroxidation. Therefore rose hip and L. plantarum may be used as a pretreatment to tissue injuries, e.g. colonic surgery, organ transplantation and vascular surgery.
结肠缺血/再灌注（I/R）是一种炎症状态，会导致组织损伤，其中活性氧发挥核心作用。玫瑰果富含具有抗氧化特性的生物活性多酚，这在预防脂质过氧化方面可能很重要。植物乳杆菌DSM 9843对多酚具有酶活性。本研究的目的是确定口服植物乳杆菌和玫瑰果对I/R损伤的影响。给予玫瑰果和植物乳杆菌可显著降低盲肠组织中的丙二醛（MDA）水平以及盲肠粪便中的肠杆菌科细菌数量。发现MDA水平与肠杆菌科细菌数量之间存在正相关。结果支持玫瑰果和植物乳杆菌在减少脂质过氧化方面具有协同/相加作用。因此，玫瑰果和植物乳杆菌可用作组织损伤（如结肠手术、器官移植和血管手术）的预处理。
