Montazeri Katayoon, Mokmeli Soheila, Barat Maryam
Laboratory for Auditory Neuroscience, ENT and Head & Neck Research Centre, Iran University of Medical Sciences, Tehran, Iran.
Canadian Optic and Laser Center (COL Center), Research Unit, Victoria BC Canada.
J Lasers Med Sci. 2017 Summer;8(Suppl 1):S22-S26. doi: 10.15171/jlms.2017.s5. Epub 2017 Aug 29.
The objective of this study was to assess the efficacy of a combination of 3 wavelengths (including red, infra-red, and blue) of low-level laser (LLL) as a non-invasive therapeutic method to reduce abdominal girth. To achieve biochemical activity on adipocytes, a red laser was used in our selective laser combination. Near-infrared laser was used to increase depth of penetration. Nitrosyl complexes of hemoglobin (NO-Hb) are sensitive to blue light, thereby leading to increase in release of biologically active nitric oxide (NO), which can affect tissue perfusion. Thus, a blue LED was added to the laser combination. Eighteen females participated in the study. Twelve sessions of laser therapy were performed, 2 sessions per week for each subject. Continuous wave diode lasers, including red (630 nm), infra-red (808 nm), and a blue LED (450 nm) were applied and were all designed by the Canadian Optic and Laser Center. Statistical analyses revealed that upper abdomen size significantly decreased from pre- (91.86 ± 11.16) to post- (87.41 ± 10.52) low-level laser therapy (LLLT) (<0.001). Middle abdomen size showed significant reduction from pre- (97.02 ± 8.82) to post- (91.97 ± 8.49) LLLT (<0.001). Lower abdomen size significantly decreased from pre- (100.36 ± 9.45) to post- (95.80 ± 8.52) LLLT (<0.001). : Based on this case series pilot investigation, the combination of 3 different wavelengths of LLL was effective for abdominal girth reduction in 100% of our subjects (<0.001), without any side effects. Future studies will assess the long-term benefits of this laser combination for reduction of subcutaneous fat deposits.
本研究的目的是评估低强度激光（LLL）三种波长（包括红色、红外线和蓝色）组合作为一种非侵入性治疗方法减少腹围的疗效。为了在脂肪细胞上实现生化活性，我们在选择性激光组合中使用了红色激光。近红外激光用于增加穿透深度。血红蛋白的亚硝酰配合物（NO-Hb）对蓝光敏感，从而导致生物活性一氧化氮（NO）释放增加，这会影响组织灌注。因此，在激光组合中添加了蓝色发光二极管。18名女性参与了该研究。对每个受试者进行了12次激光治疗，每周2次。应用了连续波二极管激光器，包括红色（630nm）、红外线（808nm）和蓝色发光二极管（450nm），均由加拿大光学与激光中心设计。统计分析显示，低强度激光治疗（LLLT）前上腹部尺寸（91.86±11.16）至治疗后（87.41±10.52）显著减小（<0.001）。中腹部尺寸在LLLT前（97.02±8.82）至治疗后（91.97±8.49）显著减小（<0.001）。下腹部尺寸从LLLT前（100.36±9.45）至治疗后（95.80±8.52）显著减小（<0.001）。基于这个病例系列的初步研究，三种不同波长的LLL组合在100%的受试者中对减少腹围有效（<0.001），且无任何副作用。未来的研究将评估这种激光组合对减少皮下脂肪沉积的长期益处。
