高剂量率微型Selectron腔内照射用于肺癌姑息治疗

Burt P A, O'Driscoll B R, Notley H M, Barber P V, Stout R

Department of Radiotherapy, Christie Hospital and Holt Radium Institute, Manchester.

Thorax. 1990 Oct;45(10):765-8. doi: 10.1136/thx.45.10.765.

Fifty patients with inoperable, symptomatic endobronchial carcinoma were treated by a single exposure of intraluminal radiotherapy. A high dose rate afterloading system (the micro-Selectron-HDR) was used to minimise radiation exposure for staff. Haemoptysis was relieved in 24 of 28 patients, breathlessness in 21 of 33 patients, and cough in nine of 18 patients. Radiological collapse resolved in 11 of 24 patients. Treatment was given on an outpatient basis and was well tolerated. Intraluminal radiotherapy appears to offer an effective alternative to conventional fractionated external beam radiotherapy.

50例有症状的无法手术的支气管内癌患者接受了单次腔内放射治疗。采用高剂量率后装系统（微型Selectron-HDR）以尽量减少工作人员的辐射暴露。28例咯血患者中有24例咯血缓解，33例气促患者中有21例气促缓解，18例咳嗽患者中有9例咳嗽缓解。24例患者中有11例放射学上的肺不张得到缓解。治疗在门诊进行，耐受性良好。腔内放射治疗似乎为传统的分次外照射放疗提供了一种有效的替代方法。