Shepherd Robert F, Conrad Jacinta C, Rhodes Summer K, Link Darren R, Marquez Manuel, Weitz David A, Lewis Jennifer A
Frederick Seitz Materials Research Laboratory, University of Illinois, Urbana, Illinois 61801, USA.
Langmuir. 2006 Oct 10;22(21):8618-22. doi: 10.1021/la060759+.
The microfluidic assembly of colloid-filled hydrogel granules of varying shape and composition is described. First, drops are formed by shearing a concentrated colloidal microsphere-acrylamide suspension in a continuous oil phase using a sheath-flow device. Both homogeneous and Janus (hemispherically distinct) spheres and disks are produced by confining the assembled drops in microchannels of varying geometry. Next, photopolymerization is carried out shortly after drop breakup to preserve their morphology. Representative wet and dried granules are characterized using fluorescence and scanning electron microscopy, respectively. Our approach offers a facile route for assembling colloid-filled hydrogel granules with controlled shape and composition.
本文描述了具有不同形状和组成的填充胶体水凝胶颗粒的微流体组装过程。首先，使用鞘流装置在连续油相中剪切浓缩的胶体微球 - 丙烯酰胺悬浮液形成液滴。通过将组装好的液滴限制在不同几何形状的微通道中，可以生产出均匀的和Janus（半球形不同）球体及圆盘。接下来，在液滴破裂后不久进行光聚合以保持其形态。分别使用荧光显微镜和扫描电子显微镜对代表性的湿颗粒和干颗粒进行表征。我们的方法为组装具有可控形状和组成的填充胶体水凝胶颗粒提供了一条简便途径。
