Brean A, Eide P K, Stubhaug Audun
Department of Neurology, County Hospital of Vestfold, Toensberg, Norway.
J Clin Monit Comput. 2006 Dec;20(6):411-4. doi: 10.1007/s10877-006-9047-7. Epub 2006 Oct 3.
We report a 48-year-old man treated for acute subarachnoid hemorrhage (SAH) wherein intracranial pressure (ICP) was measured simultaneously within the ventricular cerebrospinal fluid (CSF) and the brain parenchyma (PAR). Single pressure waves within the continuous pressure signal were identified with determination of the single wave parameters pulse amplitude (i.e. pressure difference between diastolic minimum pressure and systolic maximum pressure), mean pressure (i.e. mean pressure from beginning to ending minimum diastolic minimum pressure), and latency (i.e. rise time from diastolic minimum pressure to systolic maximum pressure). A total of 218,589 CSF/PAR single pressure wave pairs were analyzed. For these CSF/PAR wave pairs the mean difference in pulse pressure amplitude was -0.13 mmHg [95% confidence interval (CI) -0.13 to -0.12 mmHg], mean difference in mean single wave pressure -0.71 mmHg (95% CI -0.74 to -0.68 mmHg), and mean difference in latency -0.01 seconds (95% CI -0.01 to -0.01 seconds). Hence, in this patient monitoring ICP within the ventricular CSF or brain parenchyma gave similar results. Moreover, the comparisons of single CSF/PAR wave pulse pressure amplitudes gave no evidence of a pressure gradient from brain parenchyma to the ventricular CSF in this patient.
我们报告了一名48岁因急性蛛网膜下腔出血（SAH）接受治疗的男性患者，在此期间同时测量了脑室脑脊液（CSF）和脑实质（PAR）内的颅内压（ICP）。通过确定单波参数脉冲幅度（即舒张期最低压力与收缩期最高压力之间的压力差）、平均压力（即从开始到结束舒张期最低压力的平均压力）和潜伏期（即从舒张期最低压力到收缩期最高压力的上升时间）来识别连续压力信号中的单个压力波。总共分析了218,589对CSF/PAR单压力波。对于这些CSF/PAR波对，脉冲压力幅度的平均差异为-0.13 mmHg [95%置信区间（CI）-0.13至-0.12 mmHg]，单波平均压力的平均差异为-0.71 mmHg（95% CI -0.74至-0.68 mmHg），潜伏期的平均差异为-0.01秒（95% CI -0.01至-0.01秒）。因此，在该患者中，监测脑室CSF或脑实质内的ICP得出了相似的结果。此外，对单个CSF/PAR波脉冲压力幅度的比较未发现该患者存在从脑实质到脑室CSF的压力梯度证据。
