Yasui Toshiyuki, Uemura Hirokazu, Tomita Junko, Miyatani Yuka, Yamada Masayo, Kuwahara Akira, Matsuzaki Toshiya, Maegawa Masahiko, Tsuchiya Naoko, Yuzurihara Mitsutoshi, Takeda Shuichi, Irahara Minoru
Department of Obstetrics and Gynecology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770-8503, Japan.
J Clin Endocrinol Metab. 2006 Dec;91(12):4805-8. doi: 10.1210/jc.2006-1100. Epub 2006 Oct 3.
The purpose of this study was to identify serum cytokine concentrations in premenopausal, perimenopausal, and postmenopausal women and bilateral oophorectomized women with hot flashes.
Serum concentrations of 17 cytokines were simultaneously measured using a multiplexed human cytokine assay in 129 premenopausal, perimenopausal, and postmenopausal women and 50 bilateral oophorectomized women.
Serum IL-8 concentrations in midlife women and bilateral oophorectomized women with severe hot flashes were significantly higher than the concentrations in women without hot flashes and women with mild and moderate hot flashes. Serum macrophage inflammatory protein-1beta concentration in women with severe hot flashes was significantly higher than those in women without hot flashes and women with mild and moderate hot flashes.
Serum IL-8 concentrations in premenopausal, perimenopausal, and postmenopausal women and bilateral oophorectomized women with hot flashes were significantly higher than those in women without hot flashes. IL-8 may be associated with peripheral vasodilation in women with hot flashes.
本研究旨在确定绝经前、围绝经期、绝经后以及双侧卵巢切除且有潮热症状的女性血清细胞因子浓度。
采用多重人细胞因子检测法同时检测129名绝经前、围绝经期、绝经后女性以及50名双侧卵巢切除女性的17种细胞因子血清浓度。
患有严重潮热症状的中年女性和双侧卵巢切除女性的血清白细胞介素-8（IL-8）浓度显著高于无潮热症状的女性以及患有轻度和中度潮热症状的女性。患有严重潮热症状的女性血清巨噬细胞炎性蛋白-1β浓度显著高于无潮热症状的女性以及患有轻度和中度潮热症状的女性。
绝经前、围绝经期、绝经后以及双侧卵巢切除且有潮热症状的女性血清IL-8浓度显著高于无潮热症状的女性。IL-8可能与有潮热症状女性的外周血管舒张有关。
