产气克雷伯菌中甘油分解代谢的需氧和厌氧途径的独立组成型表达。
Independent constitutive expression of the aerobic and anaerobic pathways of glycerol catabolism in Klebsiella aerogenes.
作者信息
Ruch F E, Lin E C
出版信息
J Bacteriol. 1975 Oct;124(1):348-52. doi: 10.1128/jb.124.1.348-352.1975.
Abstract
Klebsiella aerogenes dissimilates glycerol aerobically via an inducible pathway initiated by an adenosine triphosphate-linked kinase that converts the substrate to sn-glycerol 3-phosphate. Phosphorylated glycerol is then dehydrogenated to dihydroxyacetone phosphate by an enzyme characteristic of a flavoprotein. Anaerobically, the organism dissimilates glycerol via an inducible pathway initiated by a nicotinamide adenine dinucleotide-linked dehydrogenase that converts the substrate to dihydroxyacetone. The keto product is then phosphorylated by another adenosine triphosphate-linked kinase. Two kinds of constitutive mutants have been isolated: one affecting the aerobic and the other the anaerobic pathway.
摘要
产气克雷伯氏菌通过一条由三磷酸腺苷连接的激酶启动的诱导途径需氧地异化甘油，该激酶将底物转化为sn-甘油3-磷酸。磷酸化的甘油随后被一种黄素蛋白特有的酶脱氢为磷酸二羟丙酮。在厌氧条件下，该生物体通过一条由烟酰胺腺嘌呤二核苷酸连接的脱氢酶启动的诱导途径异化甘油，该脱氢酶将底物转化为二羟丙酮。酮产物随后被另一种三磷酸腺苷连接的激酶磷酸化。已经分离出两种组成型突变体：一种影响需氧途径，另一种影响厌氧途径。
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