Liu Margaret A, Wahren Britta, Karlsson Hedestam Gunilla B
Transgene, Strasbourg, Cedex 67082, France.
Hum Gene Ther. 2006 Nov;17(11):1051-61. doi: 10.1089/hum.2006.17.1051.
The field of DNA vaccines continues to advance and several new strategies to augment the immunogenicity of DNA vaccines are under evaluation. The majority of these studies are in the early preclinical stage, but some DNA vaccines have moved into clinical trials. In this review, we describe some of the more recent efforts aimed at increasing the immunogenicity of DNA vaccines, including the use of genetic adjuvants and plasmid-based expression of viral replicons. In addition, we discuss the possibility of using DNA vaccines to address emerging infectious agents where they may provide an advantage over other vaccine strategies and we review some areas where DNA vaccines have been used to target self-antigens.
DNA疫苗领域持续发展，多种增强DNA疫苗免疫原性的新策略正在评估中。这些研究大多处于临床前早期阶段，但一些DNA疫苗已进入临床试验。在本综述中，我们描述了一些旨在提高DNA疫苗免疫原性的最新研究成果，包括使用基因佐剂和基于质粒的病毒复制子表达。此外，我们讨论了使用DNA疫苗应对新出现的感染因子的可能性，在这些方面DNA疫苗可能比其他疫苗策略更具优势，并且我们还综述了一些使用DNA疫苗靶向自身抗原的领域。
