Knight Chinyere A, Harris David R, Alshammari Shifaa O, Gugssa Ayele, Young Todd, Lee Clarence M
Department of Biology, Tuskegee University, Tuskegee, AL, United States.
Department of Biology, University of Hafr Al-Batin, Hafr Al-Batin, Saudi Arabia.
Front Microbiol. 2023 Feb 2;13:1052478. doi: 10.3389/fmicb.2022.1052478. eCollection 2022.
Leishmaniasis, one of the most neglected tropical diseases (NTDs), is the third most important vector-borne disease worldwide. This disease has a global impact and severity of the infection and is greatest in the Middle East. The agent of infection is a protozoan parasite of the genus, , and is generally transmitted by blood-sucking female sandflies. In humans, there are three clinical forms of infection: (1) cutaneous (CL), (2) mucocutaneous (ML), and (3) visceral leishmaniasis (VL). This review aims to discuss the current epidemiological status of leishmaniasis in Saudi Arabia, Iraq, Syria, and Yemen with a consideration of treatment options. The elevated risk of leishmaniasis is influenced by the transmission of the disease across endemic countries into neighboring non-infected regions.
利什曼病是最被忽视的热带病之一，是全球第三重要的媒介传播疾病。这种疾病具有全球影响，感染的严重程度在中东地区最为严重。感染病原体是利什曼原虫属的原生动物寄生虫，通常由吸血雌性白蛉传播。在人类中，有三种临床感染形式：（1）皮肤型（CL），（2）黏膜皮肤型（ML），以及（3）内脏利什曼病（VL）。本综述旨在讨论沙特阿拉伯、伊拉克、叙利亚和也门利什曼病的当前流行病学状况，并考虑治疗选择。利什曼病风险的升高受到该疾病在流行国家向周边未感染地区传播的影响。
