The question of FK 506 nephrotoxicity after liver transplantation.
作者信息
McCauley J, Takaya S, Fung J, Tzakis A, Abu-Elmagd K, Jain A, Todo S, Starzl T E
机构信息
Department of Surgery, University of Pittsburgh School of Medicine, PA.
出版信息
Transplant Proc. 1991 Feb;23(1 Pt 2):1444-7.
Abstract
Formal studies have not been published on the nephrotoxicity of FK 506 when the drug was used from the outset. This kind of information was sought in 101 recipients of primary livers, 24 hearts, and 3 double lungs or heart-lung. Perioperative renal dysfunction was commonly seen, which appeared to be related to FK 506 doses and plasma levels, particularly when the drug was given IV. This was reversible. Late renal function has been generally satisfactory in all three cohorts of patients, and the incidence of hypertension has been low. The therapeutic index of FK 506 is a good one, as revealed by these observations in patients whose most notable achievement was a low mortality.
摘要
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本文引用的文献
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Cyclosporine-associated chronic nephropathy.环孢素相关慢性肾病
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Nephrotoxicity of cyclosporin A in liver and kidney transplant patients.环孢素A在肝肾移植患者中的肾毒性
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Nature. 1989 Oct 26;341(6244):758-60. doi: 10.1038/341758a0.
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Nature. 1989 Oct 26;341(6244):755-7. doi: 10.1038/341755a0.
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