Leighton Timothy G
Institute of Sound and Vibration Research, Southampton University, Highfield, Southampton, SO17 1BJ, UK.
Prog Biophys Mol Biol. 2007 Jan-Apr;93(1-3):3-83. doi: 10.1016/j.pbiomolbio.2006.07.026. Epub 2006 Aug 15.
This paper is based on material presented at the start of a Health Protection Agency meeting on ultrasound and infrasound. In answering the question 'what is ultrasound?', it shows that the simple description of a wave which transports mechanical energy through the local vibration of particles at frequencies of 20 kHz or more, with no net transport of the particles themselves, can in every respect be misleading or even incorrect. To explain the complexities responsible for this, the description of ultrasound is first built up from the fundamental properties of these local particle vibrations. This progresses through an exposition of the characteristics of linear waves, in order to explain the propensity for, and properties of, the nonlinear propagation which occurs in many practical ultrasonic fields. Given the Health Protection environment which framed the original presentation, explanation and examples are given of how these complexities affect issues of practical importance. These issues include the measurement and description of fields and exposures, and the ability of ultrasound to affect tissue (through microstreaming, streaming, cavitation, heating, etc.). It is noted that there are two very distinct regimes, in terms of wave characteristics and potential for bioeffect. The first concerns the use of ultrasound in liquids/solids, for measurement or material processing. For biomedical applications (where these two processes are termed diagnosis and therapy, respectively), the issue of hazard has been studied in depth, although this has not been done to such a degree for industrial uses of ultrasound in liquids/solids (sonar, non-destructive testing, ultrasonic processing etc.). However, in the second regime, that of the use of ultrasound in air, although the waves in question tend to be of much lower intensities than those used in liquids/solids, there is a greater mismatch between the extent to which hazard has been studied, and the growth in commercial applications for airborne ultrasound.
本文基于健康保护局一次关于超声和次声会议开始时所展示的材料。在回答“什么是超声?”这个问题时,文中指出,那种简单描述为通过频率在20千赫兹及以上的粒子局部振动来传输机械能、而粒子本身并无净传输的波的说法,在各方面可能具有误导性甚至是错误的。为解释造成这种情况的复杂性,首先从这些局部粒子振动的基本特性来构建超声的描述。这一过程通过阐述线性波的特征来推进,以便解释在许多实际超声领域中发生的非线性传播的倾向和特性。鉴于最初报告所设定的健康保护环境,文中给出了解释和示例,说明这些复杂性如何影响具有实际重要性的问题。这些问题包括场和暴露的测量与描述,以及超声影响组织的能力(通过微流、声流、空化、加热等)。需要注意的是,就波的特性和生物效应的可能性而言,存在两种截然不同的情况。第一种涉及在液体/固体中使用超声进行测量或材料加工。对于生物医学应用(在这些应用中这两个过程分别称为诊断和治疗),危害问题已得到深入研究,尽管对于超声在液体/固体中的工业用途(声纳、无损检测、超声加工等)尚未达到如此程度。然而,在第二种情况中,即在空气中使用超声时,尽管所涉及的波的强度往往比在液体/固体中使用的波低得多,但在危害研究程度与机载超声商业应用增长之间存在更大的不匹配。