阿尔茨海默病嗅觉通路中的元素失衡
Elemental imbalances in the olfactory pathway in Alzheimer's disease.
作者信息
Samudralwar D L, Diprete C C, Ni B F, Ehmann W D, Markesbery W R
机构信息
Department of Chemistry, University of Kentucky, Lexington 40506, USA.
出版信息
J Neurol Sci. 1995 Jun;130(2):139-45. doi: 10.1016/0022-510x(95)00018-w.
Concentrations of 11 trace elements were determined in 56 control and 98 Alzheimer's disease (AD) olfactory bulb, olfactory tract, olfactory trigone, piriform cortex and amygdala specimens by instrumental neutron activation analysis. Iron and zinc were significantly elevated and bromine was significantly depleted in olfactory regions of AD patients, compared with normal age-matched control subjects. Elevated iron could possibly play a role in neuronal degeneration in AD by enhancing reactive free radical formation.
通过仪器中子活化分析，测定了56例对照者以及98例阿尔茨海默病（AD）患者的嗅球、嗅束、嗅三角、梨状皮质和杏仁核标本中11种微量元素的浓度。与年龄匹配的正常对照者相比，AD患者嗅觉区域的铁和锌显著升高，而溴显著减少。铁含量升高可能通过增强活性自由基的形成在AD的神经元变性中发挥作用。
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