Kumbar Sangamesh G, Nair Lakshmi S, Bhattacharyya Subhabrata, Laurencin Cato T
Department of Orthopaedic Surgery, University of Virginia, Virginia 22903, USA.
J Nanosci Nanotechnol. 2006 Sep-Oct;6(9-10):2591-607. doi: 10.1166/jnn.2006.462.
Nanotechnology and nanoscience are relatively new technological endeavors that encompass the study, control, manipulation, and assembly of multifarious nanoscale components into materials, systems and devices to serve human interest and needs. Among the various currently used nanostructures for high technology applications polymeric nanofibers have received immense interest due to the ease of fabrication, controllable size/shape, and properties. Polymeric nanofibers have been extensively investigated for diversified applications, including filtration, barrier fabrics, wipes, personal care, biomedical, and pharmaceutical applications. This review mainly focuses on the fabrication of therapeutic agent loaded polymeric nanofibers and their controlled/sustained release behavior for the delivery of these active agents for various therapeutic applications. The nonwoven biodegradable polymeric nanofiber matrices are currently being reported as topical/local therapeutic agent delivery systems and as resorbable/biodegradable gauze for wound healing applications.
纳米技术和纳米科学是相对较新的技术领域，涵盖对各种纳米级组件进行研究、控制、操纵并组装成材料、系统和设备，以满足人类的利益和需求。在目前用于高科技应用的各种纳米结构中，聚合物纳米纤维因其易于制造、尺寸/形状可控以及具备多种特性而备受关注。聚合物纳米纤维已被广泛研究用于多种应用，包括过滤、防护织物、擦拭布、个人护理、生物医学和制药应用。本综述主要聚焦于负载治疗剂的聚合物纳米纤维的制备及其用于递送这些活性剂以实现各种治疗应用的控释/缓释行为。目前，非织造可生物降解聚合物纳米纤维基质被报道可用作局部/局部治疗剂递送系统以及用于伤口愈合应用的可吸收/可生物降解纱布。
