Sharma Rahul, Singh Harmanpreet, Joshi Munish, Sharma Abhinandan, Garg Tarun, Goyal Amit Kumar, Rath Goutam
Department of Pharmaceutics, I.S.F. College of Pharmacy, Moga (Punjab), India.
Department of Pharmaceutics, ISF College of Pharmacy, Moga (Punjab), India 09501223252(M).
Crit Rev Ther Drug Carrier Syst. 2014;31(3):187-217. doi: 10.1615/critrevtherdrugcarriersyst.2014008193.
Electrospinning is a simple unit operation process by which polymeric nanofibers with diameters ranging from a few nanometers to hundreds of micrometers can be fabricated using an electrostatically operated jet of polymer solution or polymer melt. Nanofibers because of their interesting features, such as surface-to-volume ratio, high surface area, microporosity, and nonwoven structure, provide numerous opportunities to design novel carrier systems for large commodities of therapeutics. Physicochemical properties of nanofibers depend on several process and formulation parameters, such as applied voltage, flow rate, polymer selection, and concentration of polymer used. The applications of nanofibers in drug delivery are nearly unbounded. This review summarizes the most recent work done on the various physicochemical parameters of electrospinning and polymers used in making wide varieties of nanofibers along with their role in developing more effective, novel drug delivery systems.
静电纺丝是一种简单的单元操作过程，通过该过程，可以使用聚合物溶液或聚合物熔体的静电驱动射流来制造直径范围从几纳米到数百微米的聚合物纳米纤维。纳米纤维因其具有诸如表面积与体积比、高表面积、微孔性和非织造结构等有趣特性，为设计用于大量治疗药物的新型载体系统提供了众多机会。纳米纤维的物理化学性质取决于几个工艺和配方参数，如施加电压、流速、聚合物选择以及所用聚合物的浓度。纳米纤维在药物递送中的应用几乎是无限的。本综述总结了关于静电纺丝的各种物理化学参数以及用于制造各种纳米纤维的聚合物的最新研究工作，以及它们在开发更有效、新型药物递送系统中的作用。
