Liu Li-Li, Ma Zeng-Chun, Wang Yu-Guang, Qin Hong-Lin, Tan Hong-Ling, Xiao Cheng-Rong, Gao Yue
Institute of Radiation Medicine, Beijing 100850, China.
Zhongguo Zhong Yao Za Zhi. 2006 Jul;31(14):1172-5.
To study the effects of Siwu decoction on protein expression of blood deficiency mice induced by cyclophosphamide (CIX) and discuss the possible molecular mechanism on blood enriching function of Siwu decoction.
Blood deficiency mice were established by injecting ip with 250 mg x kg(-1) CTX. Proteomic technologies were applied to identify the different protein.
Siwu decoction could restore the changes of 12 up-regulated and 3 down-regulated proteins in bone marrow of blood deficiency mice induced by cyclosphosphamide.
Siwu decoction could effect expression of proteins which functions including apoptosis, proliferation and differentiation of the haematopoietic stem/progenitor cell. The regulation in the molecular level might be the mechanism of stimulating hematopoiesis in bone marrow fo siwu decocetion.
研究四物汤对环磷酰胺（CTX）致血虚小鼠蛋白质表达的影响，探讨四物汤补血作用的可能分子机制。
腹腔注射250mg·kg⁻¹CTX建立血虚小鼠模型。应用蛋白质组学技术鉴定差异蛋白质。
四物汤可使环磷酰胺致血虚小鼠骨髓中12种上调蛋白和3种下调蛋白的变化恢复正常。
四物汤可影响造血干/祖细胞凋亡、增殖和分化等功能相关蛋白的表达。这种分子水平的调控可能是四物汤促进骨髓造血的机制。
