Kouyos Roger D, Althaus Christian L, Bonhoeffer Sebastian
Institute of Integrative Biology, ETH Zurich CHN, CH-8092 Zurich, Switzerland.
Trends Microbiol. 2006 Dec;14(12):507-11. doi: 10.1016/j.tim.2006.10.001. Epub 2006 Oct 16.
Various studies have attempted to estimate the effective population size of HIV-1 to determine the strength of stochastic effects in within-host evolution. The largely discrepant estimates, the complexity of the concept of the effective population size and the resulting uncertainty about the underlying assumptions make the interpretation of these estimates difficult. Here, we explain the concept and critically assess the current estimates. We discuss the biologically relevant factors that affect the estimate and use of the effective population size. We argue that these factors lead to an underestimation of the effective population size and, thus, to an overestimation of the strength of stochastic effects in HIV-1 evolution.
多项研究试图估算HIV-1的有效种群大小，以确定宿主内进化中随机效应的强度。这些估算结果差异很大，有效种群大小概念的复杂性以及相关潜在假设的不确定性使得对这些估算结果的解读变得困难。在此，我们解释这一概念并严格评估当前的估算结果。我们讨论了影响有效种群大小估算和使用的生物学相关因素。我们认为这些因素导致了对HIV-1进化中有效种群大小的低估，进而高估了随机效应的强度。
