针对诺如病毒（基因组II型）的抗体流行率和滴度与分泌型（FUT2）相关，但与ABO血型表型或Lewis（FUT3）基因型无关。
Antibody prevalence and titer to norovirus (genogroup II) correlate with secretor (FUT2) but not with ABO phenotype or Lewis (FUT3) genotype.
作者信息
Larsson Malin Modin, Rydell Gustaf E P, Grahn Ammi, Rodriguez-Diaz Jesus, Akerlind Britt, Hutson Anne M, Estes Mary K, Larson Goran, Svensson Lennart
机构信息
Division of Molecular Virology, University of Linkoping, 581 85 Linkoping, Sweden.
出版信息
J Infect Dis. 2006 Nov 15;194(10):1422-7. doi: 10.1086/508430. Epub 2006 Oct 10.
BACKGROUND
Histo-blood group antigens and secretor status have been associated with susceptibility to Norovirus infections, which suggests that antibody prevalence and titer might correlate with these phenotypes.
METHODS
Plasma samples (n = 105) from Swedish blood donors that had been genotyped for secretor (FUT2) and Lewis (Le; FUT3) genotypes and phenotyped for ABO and Le blood groups were analyzed for immunoglobulin G antibody prevalence and titers to norovirus genogroup (GG) II.4.
RESULTS
The results showed that nonsecretors (se4128se428) and Lea+b- individuals not only had significantly lower antibody titers than did secretors (P < .0001) and Lea-b+ individuals (P < .0002) but were also significantly more often antibody negative (P < .05). Antibody titers in secretors were not significantly different between individuals of different Le (FUT3) genotypes or different ABO phenotypes.
CONCLUSIONS
Nonsecretors and Lea+b- individuals are significantly less prone to be infected with GGII noroviruses. This new information extends previous knowledge and supports the hypothesis that nonsecretors are relatively but not absolutely resistant to norovirus infections.
背景
组织血型抗原和分泌状态与诺如病毒感染的易感性相关，这表明抗体流行率和滴度可能与这些表型相关。
方法
分析了来自瑞典献血者的血浆样本（n = 105），这些样本已对分泌型（FUT2）和Lewis（Le；FUT3）基因型进行了基因分型，并对ABO和Le血型进行了表型分析，以检测针对诺如病毒基因群（GG）II.4的免疫球蛋白G抗体流行率和滴度。
结果
结果显示，非分泌者（se4128se428）和Lea+b-个体不仅抗体滴度显著低于分泌者（P <.0001）和Lea-b+个体（P <.0002），而且抗体阴性的频率也显著更高（P <.05）。不同Le（FUT3）基因型或不同ABO表型个体的分泌者抗体滴度无显著差异。
结论
非分泌者和Lea+b-个体感染GGII诺如病毒的可能性显著降低。这一新信息扩展了先前的知识，并支持非分泌者对诺如病毒感染相对但并非绝对具有抗性的假说。
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