Richard Wietske, Kox Dennis, den Herder Cindy, van Tinteren Harm, de Vries Nico
Department of Otolaryngology, Head and Neck Surgery, St Lucas Andreas Hospital, Amsterdam, The Netherlands.
Eur Arch Otorhinolaryngol. 2007 Apr;264(4):439-44. doi: 10.1007/s00405-006-0182-z. Epub 2006 Oct 25.
We evaluated the surgical results of a one tempo multilevel surgical approach of the upper airway to treat patients with obstructive sleep apnea syndrome (OSAS) in a prospective case series. Twenty-two patients with OSAS and obstruction at both palatinal and tongue base level, as assessed by sleep endoscopy, underwent UPPP, RFTB, HS with or without GA in one operative session. The mean apnea hypopnea index (AHI) decreased from 48.7 (range 17.4-100.9) to 28.8 (P < 0.0001). The success rate (AHI <20 and >50% reduction in AHI) was 45%, the response rate (reduction in AHI of 20-50%) was 27%. The overall response rate was 72%. The success rates of patients with an AHI <55 and >55 were 56 and 0%, respectively. The overall response rate of patients with an AHI <55 was 78% and >55 was 50%. Improvement of desaturation index was significant from 31.9 to 17.6 (P < 0.0001). Visual analogue scales for snoring and hypersomnolence and the Epworth Sleepiness Scores showed significant improvements too (all P < 0.0001). There was no difference in objective and subjective outcomes between the group with and without GA. This study demonstrates that one stage multilevel surgery, in which genioglossus advancement is not of additional value, is a valuable addition to the therapeutic armentarium and can be considered a viable alternative, objective as well as subjective, to NCPAP or as primary treatment in well selected patients with moderate to severe OSAS with an AHI <55.
在一项前瞻性病例系列研究中,我们评估了一种单期多级上气道手术方法治疗阻塞性睡眠呼吸暂停综合征(OSAS)患者的手术效果。通过睡眠内镜检查评估,22例腭部和舌根水平均存在阻塞的OSAS患者在一次手术中接受了悬雍垂腭咽成形术(UPPP)、舌根射频消融术(RFTB)、舌骨悬吊术(HS),部分患者接受了全身麻醉(GA)。平均呼吸暂停低通气指数(AHI)从48.7(范围17.4 - 100.9)降至28.8(P < 0.0001)。成功率(AHI <20且AHI降低>50%)为45%,有效率(AHI降低20 - 50%)为27%。总有效率为72%。AHI <55和>55的患者成功率分别为56%和0%。AHI <55的患者总有效率为78%,>55的患者为50%。去饱和指数从31.9显著改善至17.6(P < 0.0001)。打鼾和嗜睡的视觉模拟量表以及爱泼华嗜睡量表评分也显示出显著改善(均P < 0.0001)。有或无全身麻醉组的客观和主观结果无差异。本研究表明,一期多级手术(其中颏舌肌前移并无额外价值)是治疗手段中的一项有价值补充,对于AHI <55的中重度OSAS患者,在经过精心挑选后,可被视为持续气道正压通气(NCPAP)的可行替代方案,无论是客观还是主观方面,也可作为主要治疗方法。