Vlaski E, Stavric K, Isjanovska R, Seckova L, Kimovska M
Department of Pulmonology and Allergology, University Children's Hospital, Skopje, R. Macedonia.
Allergol Immunopathol (Madr). 2006 Sep-Oct;34(5):199-205. doi: 10.1157/13094027.
A positive association between body mass index (BMI) and allergic diseases has recently been suggested; however the sex-dependence of this association remains controversial. The aim of the present study was to explore the relationship between BMI and asthma and eczema, as well as its sex-dependence in young adolescents.
Self-reported data obtained through the standardized International Study of Asthma and Allergies in Childhood (ISAAC) Phase Three written questionnaires of 2926 young adolescents aged 13-14 years old from randomly selected schools in Skopje (Republic of Macedonia) were used. The BMI for each individual was calculated and used-both unadjusted and adjusted for confounding factors-as a variable for analysis. The international cut-off points for BMI for overweight and obesity by sex and age were used. Because of the very low prevalence of obesity (1.5 %), obese respondents were included in the overweight group. The data were statistically analyzed by the chi-square test, the t-test for independent samples and odds ratios (OR, 95 % CI) in binary logistic regression.
Being overweight was significantly associated with an increased risk of having a dry night cough without a cold or chest infection (adjusted OR: 1.54; 95 % CI: 1.09-2.16; p = 0.01) and with having had self-reported asthma at some time (adjusted OR: 2.36; 95 % CI: 1.02-5.44; p = 0.04) in boys only. A significant association between overweight and other symptoms of asthma or atopic eczema was not established.
These findings suggest a male-specific positive association between overweight and a current dry night cough and having received a diagnosis of asthma at some time. No association was found with other asthma symptoms or atopic eczema in young adolescents.
最近有人提出体重指数（BMI）与过敏性疾病之间存在正相关；然而，这种关联的性别依赖性仍存在争议。本研究的目的是探讨青少年中BMI与哮喘和湿疹之间的关系及其性别依赖性。
使用通过标准化的儿童哮喘和过敏国际研究（ISAAC）第三阶段书面问卷从马其顿共和国斯科普里随机选择的学校中2926名13 - 14岁青少年获得的自我报告数据。计算每个个体的BMI，并将其作为分析变量，分别进行未调整和针对混杂因素调整后的分析。使用按性别和年龄划分的超重和肥胖的国际BMI切点。由于肥胖患病率极低（1.5%），肥胖受访者被纳入超重组。数据通过卡方检验、独立样本t检验以及二元逻辑回归中的比值比（OR，95%置信区间）进行统计学分析。
超重仅在男孩中与无感冒或胸部感染的夜间干咳风险增加显著相关（调整后的OR：1.54；95%置信区间：1.09 - 2.16；p = 0.01），并且与曾有自我报告的哮喘显著相关（调整后的OR：2.36；95%置信区间：1.02 - 5.44；p = 0.04）。超重与哮喘或特应性湿疹的其他症状之间未建立显著关联。
这些发现表明超重与当前夜间干咳以及曾被诊断为哮喘之间存在男性特异性正相关。在青少年中未发现与其他哮喘症状或特应性湿疹有关联。
