Worthley Daniel-L, Bardy Peter-G, Gordon David-L, Mullighan Charles-G
Department of Gastroenterology and Hepatology, Flinders Medical Centre, Room 3D230, Bedford Park, SA, 5042, Australia.
World J Gastroenterol. 2006 Oct 28;12(40):6420-8. doi: 10.3748/wjg.v12.i40.6420.
Mannose-binding lectin (MBL) is a pattern-recognition molecule that binds to characteristic carbohydrate motifs present on the surface of many different pathogens. MBL binding stimulates the immune system via the lectin pathway of complement activation. In certain clinical situations, often characterized by pre-existing immune compromise, MBL deficiency increases the risk of infectious and other disease-specific complications. Many of the key pathogenic processes inherent to common gastroenterological diseases, such as infection, immunological damage, and carcinogenesis, have been linked to MBL. This editorial reviews the biology of MBL, outlines key disease associations to document the breadth of influence of MBL, and finally, highlights the relevance of MBL to both gastroenterological health and disease.
甘露糖结合凝集素（MBL）是一种模式识别分子，可与许多不同病原体表面存在的特征性碳水化合物基序结合。MBL结合通过补体激活的凝集素途径刺激免疫系统。在某些通常以预先存在的免疫功能低下为特征的临床情况下，MBL缺乏会增加感染及其他疾病特异性并发症的风险。许多常见胃肠疾病固有的关键致病过程，如感染、免疫损伤和致癌作用，都与MBL有关。这篇社论综述了MBL的生物学特性，概述了关键的疾病关联以证明MBL影响的广度，最后强调了MBL与胃肠健康和疾病的相关性。
