Lavin M J, Eldem B, Gregor Z J
Department of Clinical Ophthalmology, Moorfields Eye Hospital, London.
Br J Ophthalmol. 1991 Mar;75(3):133-6. doi: 10.1136/bjo.75.3.133.
The size of the final macular scar in subretinal neovascularisation (SRNV) is one of the most important determinants of final visual function in patients with subfoveal disease. We studied patients with bilateral macular scars from age-related subretinal neovascular membranes retrospectively in order to determine whether or not fellow eyes behave similarly. We found a significant correlation between eyes in terms of final scar size (r = 0.50, p less than 0.01). We found that 50% of fellow eyes with large macular scars (greater than 3 x 10(6) microns2) had similar sized lesions, while only 16% of fellow eyes with small macular scars (less than 0.5 x 10(6) microns2) had large scars (p less than 0.01). We discuss the significance of these findings in relation to the pathogenesis of subretinal neovascular membranes, and their implications for treatment.
黄斑下新生血管形成（SRNV）中最终黄斑瘢痕的大小是黄斑下疾病患者最终视觉功能的最重要决定因素之一。我们对年龄相关性黄斑下新生血管膜所致双侧黄斑瘢痕患者进行了回顾性研究，以确定对侧眼的表现是否相似。我们发现两眼在最终瘢痕大小方面存在显著相关性（r = 0.50，p小于0.01）。我们发现，50%有大的黄斑瘢痕（大于3×10⁶平方微米）的对侧眼有大小相似的病变，而只有16%有小的黄斑瘢痕（小于0.5×10⁶平方微米）的对侧眼有大的瘢痕（p小于0.01）。我们讨论了这些发现与黄斑下新生血管膜发病机制的相关性及其对治疗的意义。
