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原位卡波西肉瘤的形态学和免疫表型证据。

Morphologic and immunophenotypic evidence of in-situ Kaposi's sarcoma.

作者信息

Konstantinopoulos Panagiotis A, Dezube Bruce J, Pantanowitz Liron

机构信息

Department of Hematology/Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.

出版信息

BMC Clin Pathol. 2006 Oct 30;6:7. doi: 10.1186/1472-6890-6-7.

DOI:10.1186/1472-6890-6-7
PMID:17074096
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1634748/
Abstract

BACKGROUND

The spectrum of Kaposi's sarcoma (KS) has been expanded to include pre-KS lesions.

CASE PRESENTATION

We report, for the first time, a case providing direct histological evidence of the development of early (in-situ) KS from mediastinal lymphatic vessels in the setting of chronic lymphedema in an HIV-positive patient. Spindle-shaped and endothelial cells in these early KS-appearing lesions were immunoreactive for HHV8, D2-40 and CD34.

CONCLUSION

Our findings suggest that HHV8-infected spindle-shaped cells associated with lymphangiogenesis that evolve into KS lesions, acquire from the outset an aberrant mixed vascular and lymphatic endothelial cell phenotype.

摘要

背景

卡波西肉瘤（KS）的范围已扩大至包括KS前期病变。

病例报告

我们首次报告了1例HIV阳性患者，在慢性淋巴水肿背景下，从纵隔淋巴管发展而来的早期（原位）KS的直接组织学证据。这些早期KS样病变中的梭形细胞和内皮细胞对HHV8、D2-40和CD34呈免疫反应性。

结论

我们的研究结果表明，感染HHV8的梭形细胞与淋巴管生成相关，演变成KS病变，从一开始就获得异常的混合血管和淋巴管内皮细胞表型。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f189/1634748/d363d41367c6/1472-6890-6-7-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f189/1634748/a4d0ebbfc355/1472-6890-6-7-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f189/1634748/3aeebece8a6a/1472-6890-6-7-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f189/1634748/939e9bbf3198/1472-6890-6-7-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f189/1634748/4b25e2f08cff/1472-6890-6-7-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f189/1634748/d363d41367c6/1472-6890-6-7-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f189/1634748/a4d0ebbfc355/1472-6890-6-7-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f189/1634748/3aeebece8a6a/1472-6890-6-7-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f189/1634748/939e9bbf3198/1472-6890-6-7-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f189/1634748/4b25e2f08cff/1472-6890-6-7-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f189/1634748/d363d41367c6/1472-6890-6-7-5.jpg

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Lymphatic reprogramming of blood vascular endothelium by Kaposi sarcoma-associated herpesvirus.卡波西肉瘤相关疱疹病毒对血管内皮细胞的淋巴管重编程
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