Chavarro Jorge E, Rich-Edwards Janet W, Rosner Bernard A, Willett Walter C
Department of Nutrition and Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
Obstet Gynecol. 2006 Nov;108(5):1145-52. doi: 10.1097/01.AOG.0000238333.37423.ab.
To evaluate whether iron supplement use or greater intake of total, heme and nonheme iron is associated with lower risk of ovulatory infertility.
We conducted a prospective cohort study among 18,555 married, premenopausal women without a history of infertility who attempted a pregnancy or became pregnant between 1991 and 1999 (mean baseline age+/-standard deviation 32.6+/-3.6). Diet was assessed twice during follow-up and prospectively related to the incidence of infertility due to ovulatory disorder.
During the 8 years of follow-up, 438 women reported infertility due to ovulatory disorder. Women who consumed iron supplements had a significantly lower risk of ovulatory infertility than women who did not use iron supplements (relative risk 0.60, 95% confidence interval 0.39-0.92), after adjusting for potential confounders. Total nonheme iron intake, primarily consumed as multivitamins and iron supplements, was inversely associated with the risk of infertility (relative risk Quintile 1 compared with 5, 95% confidence interval 0.39-0.92; P, trend .005.) Heme iron intake was unrelated to ovulatory infertility in multivariable adjusted analyses.
Consumption of iron supplements and nonheme iron from other sources may decrease the risk of ovulatory infertility.
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评估补充铁剂或增加总铁、血红素铁和非血红素铁的摄入量是否与排卵性不孕症风险降低相关。
我们对18555名已婚、未绝经且无不孕史的女性进行了一项前瞻性队列研究，这些女性在1991年至1999年期间尝试怀孕或已怀孕（平均基线年龄±标准差为32.6±3.6）。在随访期间对饮食进行了两次评估，并前瞻性地分析其与排卵障碍所致不孕症发生率的关系。
在8年的随访期间，438名女性报告因排卵障碍导致不孕。在调整潜在混杂因素后，服用铁补充剂的女性排卵性不孕风险显著低于未服用铁补充剂的女性（相对风险0.60，95%置信区间0.39 - 0.92）。主要通过多种维生素和铁补充剂摄入的总非血红素铁摄入量与不孕风险呈负相关（与第5分位数相比，第1分位数的相对风险，95%置信区间0.39 - 0.92；P趋势 = 0.005）。在多变量调整分析中，血红素铁摄入量与排卵性不孕无关。
服用铁补充剂和从其他来源摄入非血红素铁可能会降低排卵性不孕的风险。
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